Selective transport systems mediate sequestration of plant glucosides in leaf beetles: A molecular basis for adaptation and evolution Export

@article{citeulike:4518043, abstract = {10.1073/pnas.0402576101 Chrysomeline larvae respond to disturbance and attack by everting dorsal glandular reservoirs, which release defensive secretions. The ancestral defense is based on the synthesis of monoterpene iridoids. The catabolization of the host-plant -glucoside salicin into salicylaldehyde is a character state that evolved later in two distinct lineages, which specialized on Salicaceae. By using two species producing monoterpenes ( and ) and two sequestering species ( and ), we studied the molecular basis of sequestration by feeding the larvae structurally different thioglucosides resembling natural -glucosides. Their accumulation in the defensive systems demonstrated that the larvae possess transport systems, which are evolutionarily adapted to the glycosides of their host plants. Minor structural modifications in the aglycon result in drastically reduced transport rates of the test compounds. Moreover, the ancestral iridoid-producing leaf beetles already possess a fully functional import system for an early precursor of the iridoid defenses. Our data confirm an evolutionary scenario in which, after a host-plant change, the transport system of the leaf beetles may play a pivotal role in the adaptation on new hosts by selecting plant-derived glucosides that can be channeled to the defensive system.}, author = {Kuhn, J\"{u}rgen and Pettersson, Eva M. and Feld, Birte K. and Burse, Antje and Termonia, Arnaud and Pasteels, Jacques M. and Boland, Wilhelm}, citeulike-article-id = {4518043}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0402576101}, citeulike-linkout-1 = {http://www.pnas.org/content/101/38/13808.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/101/38/13808.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/15365181}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=15365181}, day = {21}, doi = {10.1073/pnas.0402576101}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {beetle, evolution, glucosides, leaf, molecular}, month = {September}, number = {38}, pages = {13808--13813}, posted-at = {2009-05-14 13:40:14}, priority = {2}, title = {Selective transport systems mediate sequestration of plant glucosides in leaf beetles: A molecular basis for adaptation and evolution}, url = {http://dx.doi.org/10.1073/pnas.0402576101}, volume = {101}, year = {2004} }

TY - JOUR ID - citeulike:4518043 L3 - citeulike-article-id:4518043 N2 - 10.1073/pnas.0402576101 Chrysomeline larvae respond to disturbance and attack by everting dorsal glandular reservoirs, which release defensive secretions. The ancestral defense is based on the synthesis of monoterpene iridoids. The catabolization of the host-plant -glucoside salicin into salicylaldehyde is a character state that evolved later in two distinct lineages, which specialized on Salicaceae. By using two species producing monoterpenes ( and ) and two sequestering species ( and ), we studied the molecular basis of sequestration by feeding the larvae structurally different thioglucosides resembling natural -glucosides. Their accumulation in the defensive systems demonstrated that the larvae possess transport systems, which are evolutionarily adapted to the glycosides of their host plants. Minor structural modifications in the aglycon result in drastically reduced transport rates of the test compounds. Moreover, the ancestral iridoid-producing leaf beetles already possess a fully functional import system for an early precursor of the iridoid defenses. Our data confirm an evolutionary scenario in which, after a host-plant change, the transport system of the leaf beetles may play a pivotal role in the adaptation on new hosts by selecting plant-derived glucosides that can be channeled to the defensive system. IS - 38 JF - Proceedings of the National Academy of Sciences of the United States of America EP - 13813 TI - Selective transport systems mediate sequestration of plant glucosides in leaf beetles: A molecular basis for adaptation and evolution VL - 101 SP - 13808 KW - beetle KW - evolution KW - glucosides KW - leaf KW - molecular AU - Kuhn, Jürgen AU - Pettersson, Eva AU - Feld, Birte AU - Burse, Antje AU - Termonia, Arnaud AU - Pasteels, Jacques AU - Boland, Wilhelm PY - 2004/09/21/ UR - http://dx.doi.org/10.1073/pnas.0402576101 ER -