The genetics of quantitative traits: challenges and prospects Export

@article{citeulike:5189733, abstract = {A major challenge in current biology is to understand the genetic basis of variation for quantitative traits. We review the principles of quantitative trait locus mapping and summarize insights about the genetic architecture of quantitative traits that have been obtained over the past decades. We are currently in the midst of a genomic revolution, which enables us to incorporate genetic variation in transcript abundance and other intermediate molecular phenotypes into a quantitative trait locus mapping framework. This systems genetics approach enables us to understand the biology inside the 'black box' that lies between genotype and phenotype in terms of causal networks of interacting genes.}, author = {Mackay, Trudy F. C. and Stone, Eric A. and Ayroles, Julien F.}, citeulike-article-id = {5189733}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2612}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2612}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19584810}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19584810}, day = {7}, doi = {10.1038/nrg2612}, issn = {1471-0064}, journal = {Nat Rev Genet}, keywords = {association, genetics, qtl}, month = {August}, number = {8}, pages = {565--577}, posted-at = {2009-07-22 16:46:03}, priority = {2}, publisher = {Nature Publishing Group}, title = {The genetics of quantitative traits: challenges and prospects}, url = {http://dx.doi.org/10.1038/nrg2612}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5189733 L3 - citeulike-article-id:5189733 N2 - A major challenge in current biology is to understand the genetic basis of variation for quantitative traits. We review the principles of quantitative trait locus mapping and summarize insights about the genetic architecture of quantitative traits that have been obtained over the past decades. We are currently in the midst of a genomic revolution, which enables us to incorporate genetic variation in transcript abundance and other intermediate molecular phenotypes into a quantitative trait locus mapping framework. This systems genetics approach enables us to understand the biology inside the 'black box' that lies between genotype and phenotype in terms of causal networks of interacting genes. IS - 8 JF - Nat Rev Genet SN - 1471-0064 EP - 577 TI - The genetics of quantitative traits: challenges and prospects PB - Nature Publishing Group VL - 10 SP - 565 KW - association KW - genetics KW - qtl AU - Mackay, Trudy AU - Stone, Eric AU - Ayroles, Julien PY - 2009/08/07/ UR - http://dx.doi.org/10.1038/nrg2612 ER -