Restoration of torque in defective flagellar motors

by: DF Blair, HC Berg

Science, Vol. 242, No. 4886. (23 December 1988), pp. 1678-1681.

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Abstract

Paralyzed motors of motA and motB point and deletion mutants of Escherichia coli were repaired by synthesis of wild-type protein. As found earlier with a point mutant of motB, torque was restored in a series of equally spaced steps. The size of the steps was the same for both MotA and MotB. Motors with one torque generator spent more time spinning counterclockwise than did motors with two or more generators. In deletion mutants, stepwise decreases in torque, rare in point mutants, were common. Several cells stopped accelerating after eight steps, suggesting that the maximum complement of torque generators is eight. Each generator appears to contain both MotA and MotB. 10.1126/science.2849208

@article{Blair1988, abstract = {Paralyzed motors of motA and motB point and deletion mutants of Escherichia coli were repaired by synthesis of wild-type protein. As found earlier with a point mutant of motB, torque was restored in a series of equally spaced steps. The size of the steps was the same for both MotA and MotB. Motors with one torque generator spent more time spinning counterclockwise than did motors with two or more generators. In deletion mutants, stepwise decreases in torque, rare in point mutants, were common. Several cells stopped accelerating after eight steps, suggesting that the maximum complement of torque generators is eight. Each generator appears to contain both MotA and MotB. 10.1126/science.2849208}, author = {Blair, D. F. and Berg, H. C. }, citeulike-article-id = {2746755}, doi = {http://dx.doi.org/10.1126/science.2849208}, journal = {Science}, keywords = {bacteria\_flagella\_project, biophysics}, month = {December}, number = {4886}, pages = {1678--1681}, posted-at = {2008-05-02 19:22:05}, priority = {2}, title = {Restoration of torque in defective flagellar motors}, url = {http://dx.doi.org/10.1126/science.2849208}, volume = {242}, year = {1988} }

RIS record

TY - JOUR ID - Blair1988 L3 - citeulike-article-id:2746755 TI - Restoration of torque in defective flagellar motors JF - Science VL - 242 IS - 4886 SP - 1678 EP - 1681 N2 - Paralyzed motors of motA and motB point and deletion mutants of Escherichia coli were repaired by synthesis of wild-type protein. As found earlier with a point mutant of motB, torque was restored in a series of equally spaced steps. The size of the steps was the same for both MotA and MotB. Motors with one torque generator spent more time spinning counterclockwise than did motors with two or more generators. In deletion mutants, stepwise decreases in torque, rare in point mutants, were common. Several cells stopped accelerating after eight steps, suggesting that the maximum complement of torque generators is eight. Each generator appears to contain both MotA and MotB. 10.1126/science.2849208 KW - bacteria_flagella_project KW - biophysics AU - Blair, DF AU - Berg, HC PY - 1988/12/23/ UR - http://dx.doi.org/10.1126/science.2849208 ER -

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