Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences* Export

@article{citeulike:2837886, abstract = {Expected and observed effects of volume exclusion on the free energy of rigid and flexible macromolecules in crowded and confined systems, and consequent effects of crowding and confinement on macromolecular reaction rates and equilibria are summarized. Findings from relevant theoretical/simulation and experimental literature published from 2004 onward are reviewed. Additional complexity arising from the heterogeneity of local environments in biological media, and the presence of nonspecific interactions between macromolecules over and above steric repulsion, are discussed. Theoretical and experimental approaches to the characterization of crowding- and confinement-induced effects in systems approaching the complexity of living organisms are suggested.}, author = {Zhou, Huan X. and Rivas, Germ\'{a}n and Minton, Allen P.}, citeulike-article-id = {2837886}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.biophys.37.032807.125817}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.biophys.37.032807.125817}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18573087}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18573087}, doi = {10.1146/annurev.biophys.37.032807.125817}, journal = {Annual Review of Biophysics}, keywords = {biophysics, confinement, molecular, review}, number = {1}, pages = {375--397}, posted-at = {2009-07-04 20:03:18}, priority = {2}, title = {Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences*}, url = {http://dx.doi.org/10.1146/annurev.biophys.37.032807.125817}, volume = {37}, year = {2008} }

TY - JOUR ID - citeulike:2837886 L3 - citeulike-article-id:2837886 N2 - Expected and observed effects of volume exclusion on the free energy of rigid and flexible macromolecules in crowded and confined systems, and consequent effects of crowding and confinement on macromolecular reaction rates and equilibria are summarized. Findings from relevant theoretical/simulation and experimental literature published from 2004 onward are reviewed. Additional complexity arising from the heterogeneity of local environments in biological media, and the presence of nonspecific interactions between macromolecules over and above steric repulsion, are discussed. Theoretical and experimental approaches to the characterization of crowding- and confinement-induced effects in systems approaching the complexity of living organisms are suggested. IS - 1 JF - Annual Review of Biophysics EP - 397 TI - Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences* VL - 37 SP - 375 KW - biophysics KW - confinement KW - molecular KW - review AU - Zhou, Huan AU - Rivas, Germán AU - Minton, Allen PY - 2008/// UR - http://dx.doi.org/10.1146/annurev.biophys.37.032807.125817 ER -