The leukemic stem cell niche - current concepts and therapeutic opportunities. Export

@article{citeulike:4845498, abstract = {The genetic events that contribute to the pathogenesis of acute myeloid leukemia (AML) are among the best characterized of all human malignancies. However, with notable exceptions such as acute promyelocytic leukemia, significant improvements in outcome based on these insights have not been forthcoming. AML is a paradigm of cancer stem (or leukemia initiating) cells with hierarchy analogous to that seen in hematopoiesis. Normal hematopoiesis requires complex bidirectional interactions between the bone marrow microenvironment (or niche) and hematopoietic stem cells (HSC). These interactions are critical for the maintenance of normal HSC quiescence and perturbations can influence HSC self-renewal. Leukemia stem cells (LSC), that also possess limitless self-renewal, may hijack these homeostatic mechanisms, take refuge within the sanctuary of the niche during chemotherapy and consequently contribute to eventual disease relapse. We will discuss the emerging evidence supporting the importance of the bone marrow microenvironment in LSC survival and consider the physiological interactions of HSC and the niche that inform our understanding of microenvironmental support of LSC. Finally, we will discuss approaches for the rational development of therapies that target the microenvironment.}, author = {Lane, Steven W. and Scadden, David T. and Gilliland, D. Gary}, citeulike-article-id = {4845498}, citeulike-linkout-0 = {http://dx.doi.org/10.1182/blood-2009-01-202606}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19401558}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19401558}, day = {28}, doi = {10.1182/blood-2009-01-202606}, issn = {1528-0020}, journal = {Blood}, keywords = {genetics, medicine, stem}, month = {April}, posted-at = {2009-06-14 14:33:49}, priority = {2}, title = {The leukemic stem cell niche - current concepts and therapeutic opportunities.}, url = {http://dx.doi.org/10.1182/blood-2009-01-202606}, year = {2009} }

TY - JOUR ID - citeulike:4845498 L3 - citeulike-article-id:4845498 N2 - The genetic events that contribute to the pathogenesis of acute myeloid leukemia (AML) are among the best characterized of all human malignancies. However, with notable exceptions such as acute promyelocytic leukemia, significant improvements in outcome based on these insights have not been forthcoming. AML is a paradigm of cancer stem (or leukemia initiating) cells with hierarchy analogous to that seen in hematopoiesis. Normal hematopoiesis requires complex bidirectional interactions between the bone marrow microenvironment (or niche) and hematopoietic stem cells (HSC). These interactions are critical for the maintenance of normal HSC quiescence and perturbations can influence HSC self-renewal. Leukemia stem cells (LSC), that also possess limitless self-renewal, may hijack these homeostatic mechanisms, take refuge within the sanctuary of the niche during chemotherapy and consequently contribute to eventual disease relapse. We will discuss the emerging evidence supporting the importance of the bone marrow microenvironment in LSC survival and consider the physiological interactions of HSC and the niche that inform our understanding of microenvironmental support of LSC. Finally, we will discuss approaches for the rational development of therapies that target the microenvironment. JF - Blood SN - 1528-0020 TI - The leukemic stem cell niche - current concepts and therapeutic opportunities. KW - genetics KW - medicine KW - stem AU - Lane, Steven AU - Scadden, David AU - Gilliland, Gary PY - 2009/04/28/ UR - http://dx.doi.org/10.1182/blood-2009-01-202606 ER -