Stem Cell Proliferation and Quiescence—Two Sides of the Same Coin Export

@article{citeulike:5260196, abstract = {Author Summary Hematopoietic stem cells (HSCs) are among the best-studied populations of adult stem cells. Commonly HSCs are considered to be in a so called quiescent state of reduced cellular turnover. However, it appears that even quiescent HSCs are activated into the cell cycle from time to time to support the continuous production of peripheral blood. Previous reports on cell kinetic studies using specific chromosomal labeling techniques suggest that all HSCs regularly undergo cell divisions on average once in two weeks. However, these results are challenged by recent experimental findings supporting the idea that HSC populations are heterogeneous with respect to their cell cycle activity. Applying an established model of HSC organization, we demonstrate that different data sets can be consistently explained by the assumption that HSCs are reversibly switching between a quiescent and an activated state. Based on this assumption, we provide a functional explanation for the experimentally observed biphasic label dilution kinetics of HSCs. We conclude that the ability of these cells to reversibly change between proliferation and quiescence is a critical and inherent property of the HSC system necessary for the sustained balance between stem cell self-renewal and the maintenance of functional blood cells.}, author = {Glauche, Ingmar and Moore, Kateri and Thielecke, Lars and Horn, Katrin and Loeffler, Markus and Roeder, Ingo}, citeulike-article-id = {5260196}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pcbi.1000447}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19629161}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19629161}, day = {24}, doi = {10.1371/journal.pcbi.1000447}, issn = {1553-7358}, journal = {PLoS Comput Biol}, keywords = {genetics, medicine, mesophysics, stem}, month = {July}, number = {7}, pages = {e1000447+}, posted-at = {2009-07-25 11:38:36}, priority = {2}, publisher = {Public Library of Science}, title = {Stem Cell Proliferation and Quiescence—Two Sides of the Same Coin}, url = {http://dx.doi.org/10.1371/journal.pcbi.1000447}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:5260196 L3 - citeulike-article-id:5260196 N2 - Author Summary Hematopoietic stem cells (HSCs) are among the best-studied populations of adult stem cells. Commonly HSCs are considered to be in a so called quiescent state of reduced cellular turnover. However, it appears that even quiescent HSCs are activated into the cell cycle from time to time to support the continuous production of peripheral blood. Previous reports on cell kinetic studies using specific chromosomal labeling techniques suggest that all HSCs regularly undergo cell divisions on average once in two weeks. However, these results are challenged by recent experimental findings supporting the idea that HSC populations are heterogeneous with respect to their cell cycle activity. Applying an established model of HSC organization, we demonstrate that different data sets can be consistently explained by the assumption that HSCs are reversibly switching between a quiescent and an activated state. Based on this assumption, we provide a functional explanation for the experimentally observed biphasic label dilution kinetics of HSCs. We conclude that the ability of these cells to reversibly change between proliferation and quiescence is a critical and inherent property of the HSC system necessary for the sustained balance between stem cell self-renewal and the maintenance of functional blood cells. IS - 7 JF - PLoS Comput Biol SN - 1553-7358 TI - Stem Cell Proliferation and Quiescence—Two Sides of the Same Coin PB - Public Library of Science VL - 5 SP - e1000447 KW - genetics KW - medicine KW - mesophysics KW - stem AU - Glauche, Ingmar AU - Moore, Kateri AU - Thielecke, Lars AU - Horn, Katrin AU - Loeffler, Markus AU - Roeder, Ingo PY - 2009/07/24/ UR - http://dx.doi.org/10.1371/journal.pcbi.1000447 ER -