A new approach to protein fold recognition Export

@article{citeulike:1044632, abstract = {The prediction of protein tertiary structure from sequence using molecular energy calculations has not yet been successful; an alternative strategy of recognizing known motifs or folds in sequences looks more promising. We present here a new approach to fold recognition, whereby sequences are fitted directly onto the backbone coordinates of known protein structures. Our method for protein fold recognition involves automatic modelling of protein structures using a given sequence, and is based on the frameworks of known protein folds. The plausibility of each model, and hence the degree of compatibility between the sequence and the proposed structure, is evaluated by means of a set of empirical potentials derived from proteins of known structure. The novel aspect of our approach is that the matching of sequences to backbone coordinates is performed in full three-dimensional space, incorporating specific pair interactions explicitly.}, address = {Department of Biochemistry and Molecular Biology, University College, London, UK.}, author = {Jones, D. T. and Taylort, W. R. and Thornton, J. M.}, citeulike-article-id = {1044632}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/358086a0}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/358086a0}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/1614539}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=1614539}, day = {2}, doi = {10.1038/358086a0}, issn = {0028-0836}, journal = {Nature}, keywords = {post-defense, statpot, threading}, month = {July}, number = {6381}, pages = {86--89}, posted-at = {2009-05-19 19:06:44}, priority = {2}, title = {A new approach to protein fold recognition}, url = {http://dx.doi.org/10.1038/358086a0}, volume = {358}, year = {1992} }

TY - JOUR ID - citeulike:1044632 L3 - citeulike-article-id:1044632 N2 - The prediction of protein tertiary structure from sequence using molecular energy calculations has not yet been successful; an alternative strategy of recognizing known motifs or folds in sequences looks more promising. We present here a new approach to fold recognition, whereby sequences are fitted directly onto the backbone coordinates of known protein structures. Our method for protein fold recognition involves automatic modelling of protein structures using a given sequence, and is based on the frameworks of known protein folds. The plausibility of each model, and hence the degree of compatibility between the sequence and the proposed structure, is evaluated by means of a set of empirical potentials derived from proteins of known structure. The novel aspect of our approach is that the matching of sequences to backbone coordinates is performed in full three-dimensional space, incorporating specific pair interactions explicitly. IS - 6381 JF - Nature SN - 0028-0836 AD - Department of Biochemistry and Molecular Biology, University College, London, UK. EP - 89 TI - A new approach to protein fold recognition VL - 358 SP - 86 KW - post-defense KW - statpot KW - threading AU - Jones, DT AU - Taylort, WR AU - Thornton, JM PY - 1992/07/02/ UR - http://dx.doi.org/10.1038/358086a0 ER -