The genome-wide distribution of background linkage disequilibrium in a population isolate Export

@article{citeulike:3111869, abstract = {Recent interest in using association studies to investigate complex traits has focused attention on understanding linkage disequilibrium (LD) in the human genome. We examined the genome-wide distribution and magnitude of such background LD (BLD) using 1036 densely spaced microsatellites, in a sample from the demographically well characterized population of the Central Valley of Costa Rica. High levels of BLD were found between linked markers several centiMorgans apart, and although BLD was significantly related to genetic distance between markers it was not spread uniformly throughout the genome. Understanding the forces governing the distribution of BLD in the genome will require similar investigations using a standard set of markers in other populations. 10.1093/hmg/10.5.545}, author = {Service, Susan K. and Ophoff, Roel A. and Freimer, Nelson B.}, citeulike-article-id = {3111869}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/hmg/10.5.545}, citeulike-linkout-1 = {http://hmg.oxfordjournals.org/cgi/content/abstract/10/5/545}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11181579}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11181579}, day = {1}, doi = {10.1093/hmg/10.5.545}, journal = {Hum. Mol. Genet.}, keywords = {phylogenetics}, month = {March}, number = {5}, pages = {545--551}, posted-at = {2008-08-12 14:11:54}, priority = {2}, title = {The genome-wide distribution of background linkage disequilibrium in a population isolate}, url = {http://dx.doi.org/10.1093/hmg/10.5.545}, volume = {10}, year = {2001} }

TY - JOUR ID - citeulike:3111869 L3 - citeulike-article-id:3111869 N2 - Recent interest in using association studies to investigate complex traits has focused attention on understanding linkage disequilibrium (LD) in the human genome. We examined the genome-wide distribution and magnitude of such background LD (BLD) using 1036 densely spaced microsatellites, in a sample from the demographically well characterized population of the Central Valley of Costa Rica. High levels of BLD were found between linked markers several centiMorgans apart, and although BLD was significantly related to genetic distance between markers it was not spread uniformly throughout the genome. Understanding the forces governing the distribution of BLD in the genome will require similar investigations using a standard set of markers in other populations. 10.1093/hmg/10.5.545 IS - 5 JF - Hum. Mol. Genet. EP - 551 TI - The genome-wide distribution of background linkage disequilibrium in a population isolate VL - 10 SP - 545 KW - phylogenetics AU - Service, Susan AU - Ophoff, Roel AU - Freimer, Nelson PY - 2001/03/01/ UR - http://dx.doi.org/10.1093/hmg/10.5.545 ER -