Balancing reversion of CTL and neutralizing antibody escape mutations within HIV-1 Env upon transmission. Export

@article{citeulike:5041333, abstract = {HIV-1 envelope protein (Env) is subject to both neutralizing antibody (NAb) and CD8 T cell (CTL) immune pressure. We studied the reversion of Env CTL escape mutant virus to wild-type and the relationship between the reversion of CTL mutations with N-linked glycosylation site (NLGS)-driven NAb escape in pigtailed macaques. Env CTL mutations either did not revert to wild type or only transiently reverted 5-7 weeks after infection. CTL escape mutant reversion was coincident, on the same viral clones, with loss of NLGS mutations. At one site studied, both CTL and NLGS mutations were needed to confer NAb escape. We conclude CTL and NAb escape within Env can be tightly linked, suggesting opportunities to induce effective multi-component, anti-Env immunity.}, author = {Peut, Viv and Campbell, Shahan and Gaeguta, Adriana and Center, Rob J. and Wilson, Kim and Alcantara, Sheilajen and Fernandez, Caroline S. and Purcell, Damian F. and Kent, Stephen J.}, citeulike-article-id = {5041333}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/JVI.00599-09}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19515763}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19515763}, day = {10}, doi = {10.1128/JVI.00599-09}, issn = {1098-5514}, journal = {Journal of virology}, keywords = {computation, ctl}, month = {June}, posted-at = {2009-07-02 13:08:38}, priority = {2}, title = {Balancing reversion of CTL and neutralizing antibody escape mutations within HIV-1 Env upon transmission.}, url = {http://dx.doi.org/10.1128/JVI.00599-09}, year = {2009} }

TY - JOUR ID - citeulike:5041333 L3 - citeulike-article-id:5041333 N2 - HIV-1 envelope protein (Env) is subject to both neutralizing antibody (NAb) and CD8 T cell (CTL) immune pressure. We studied the reversion of Env CTL escape mutant virus to wild-type and the relationship between the reversion of CTL mutations with N-linked glycosylation site (NLGS)-driven NAb escape in pigtailed macaques. Env CTL mutations either did not revert to wild type or only transiently reverted 5-7 weeks after infection. CTL escape mutant reversion was coincident, on the same viral clones, with loss of NLGS mutations. At one site studied, both CTL and NLGS mutations were needed to confer NAb escape. We conclude CTL and NAb escape within Env can be tightly linked, suggesting opportunities to induce effective multi-component, anti-Env immunity. JF - Journal of virology SN - 1098-5514 TI - Balancing reversion of CTL and neutralizing antibody escape mutations within HIV-1 Env upon transmission. KW - computation KW - ctl AU - Peut, Viv AU - Campbell, Shahan AU - Gaeguta, Adriana AU - Center, Rob AU - Wilson, Kim AU - Alcantara, Sheilajen AU - Fernandez, Caroline AU - Purcell, Damian AU - Kent, Stephen PY - 2009/06/10/ UR - http://dx.doi.org/10.1128/JVI.00599-09 ER -