Multiple mechanisms of CB1 cannabinoid receptors regulation Export

@article{citeulike:2317999, abstract = {Agonist-induced regulation of cannabinoid CB1 receptors was examined in HEK-293 cells transfected with CB1 receptors and in neuroblastoma N18TG2 cells that naturally express CB1 receptors. In HEK-293 cells, CB1 receptors internalization proceeded, in parallel, via clathrin-coated pits and caveolae. Simultaneous disruption of both pathways induced compensatory endocytic mechanism(s). In N18TG2 cells, endocytosis was not mediated by caveolae-like membrane domains. Heterologous, opioid-induced, downregulation of CB1 receptors was evident in HEK-293 but not N18TG2 cells. The data demonstrate the existence of multiple pathways of CB1 receptors regulation.}, author = {Keren, Ora and Sarne, Yosef}, citeulike-article-id = {2317999}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0006-8993(03)02970-6}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6SYR-48S38RT-H/2/bb617a49bf7166157c2f63a0ad091e66}, day = {8}, doi = {10.1016/S0006-8993(03)02970-6}, journal = {Brain Research}, keywords = {cannabinoid, receptors}, month = {August}, number = {2}, pages = {197--205}, posted-at = {2008-09-13 03:11:27}, priority = {2}, title = {Multiple mechanisms of CB1 cannabinoid receptors regulation}, url = {http://dx.doi.org/10.1016/S0006-8993(03)02970-6}, volume = {980}, year = {2003} }

TY - JOUR ID - citeulike:2317999 L3 - citeulike-article-id:2317999 N2 - Agonist-induced regulation of cannabinoid CB1 receptors was examined in HEK-293 cells transfected with CB1 receptors and in neuroblastoma N18TG2 cells that naturally express CB1 receptors. In HEK-293 cells, CB1 receptors internalization proceeded, in parallel, via clathrin-coated pits and caveolae. Simultaneous disruption of both pathways induced compensatory endocytic mechanism(s). In N18TG2 cells, endocytosis was not mediated by caveolae-like membrane domains. Heterologous, opioid-induced, downregulation of CB1 receptors was evident in HEK-293 but not N18TG2 cells. The data demonstrate the existence of multiple pathways of CB1 receptors regulation. IS - 2 JF - Brain Research EP - 205 TI - Multiple mechanisms of CB1 cannabinoid receptors regulation VL - 980 SP - 197 KW - cannabinoid KW - receptors AU - Keren, Ora AU - Sarne, Yosef PY - 2003/08/08/ UR - http://dx.doi.org/10.1016/S0006-8993(03)02970-6 ER -