Explaining microbial population genomics through phage predation Export

@article{citeulike:5961472, abstract = {The remarkable differences that have been detected by metagenomics in the genomes of strains of the same bacterial species are difficult to reconcile with the widely accepted paradigm that periodic selection within bacterial populations will regularly purge genomic diversity by clonal replacement. We have found that many of the genes that differ between strains affect regions that are potential phage recognition targets. We therefore propose the constant-diversity dynamics model, in which the diversity of prokaryotic populations is preserved by phage predation. We provide supporting evidence for this model from metagenomics, mathematical analysis and computer simulations. Periodic selection and phage predation dynamics are not mutually exclusive; we compare their predictions to shed light on the ecological circumstances under which each type of dynamics could predominate.}, author = {Rodriguez-Valera, Francisco and Martin-Cuadrado, Ana-Belen and Rodriguez-Brito, Beltran and Pasic, Lejla and Thingstad, T. Frede and Rohwer, Forest and Mira, Alex}, citeulike-article-id = {5961472}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrmicro2235}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrmicro2235}, day = {01}, doi = {10.1038/nrmicro2235}, issn = {1740-1526}, journal = {Nature Reviews Microbiology}, keywords = {ecological\_theory, phage, virus}, month = {November}, number = {11}, pages = {828--836}, posted-at = {2009-10-19 11:20:30}, priority = {2}, publisher = {Nature Publishing Group}, title = {Explaining microbial population genomics through phage predation}, url = {http://dx.doi.org/10.1038/nrmicro2235}, volume = {7}, year = {2009} }

TY - JOUR ID - citeulike:5961472 L3 - citeulike-article-id:5961472 N2 - The remarkable differences that have been detected by metagenomics in the genomes of strains of the same bacterial species are difficult to reconcile with the widely accepted paradigm that periodic selection within bacterial populations will regularly purge genomic diversity by clonal replacement. We have found that many of the genes that differ between strains affect regions that are potential phage recognition targets. We therefore propose the constant-diversity dynamics model, in which the diversity of prokaryotic populations is preserved by phage predation. We provide supporting evidence for this model from metagenomics, mathematical analysis and computer simulations. Periodic selection and phage predation dynamics are not mutually exclusive; we compare their predictions to shed light on the ecological circumstances under which each type of dynamics could predominate. IS - 11 JF - Nature Reviews Microbiology SN - 1740-1526 EP - 836 TI - Explaining microbial population genomics through phage predation PB - Nature Publishing Group VL - 7 SP - 828 KW - ecological_theory KW - phage KW - virus AU - Rodriguez-Valera, Francisco AU - Martin-Cuadrado, Ana-Belen AU - Rodriguez-Brito, Beltran AU - Pasic, Lejla AU - Thingstad, Frede AU - Rohwer, Forest AU - Mira, Alex PY - 2009/11/01/ UR - http://dx.doi.org/10.1038/nrmicro2235 ER -