Genome evolution and adaptation in a long-term experiment with Escherichia coli. Export

@article{citeulike:5961524, abstract = {The relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentally evolving populations offers the opportunity to investigate this relationship with new precision. Here we sequence genomes sampled through 40,000 generations from a laboratory population of Escherichia coli. Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000 generations. Such clock-like regularity is usually viewed as the signature of neutral evolution, but several lines of evidence indicate that almost all of these mutations were beneficial. This same population later evolved an elevated mutation rate and accumulated hundreds of additional mutations dominated by a neutral signature. Thus, the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment. In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable.}, author = {Barrick, Jeffrey E. and Yu, Dong Su S. and Yoon, Sung Ho H. and Jeong, Haeyoung and Oh, Tae Kwang K. and Schneider, Dominique and Lenski, Richard E. and Kim, Jihyun F.}, citeulike-article-id = {5961524}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature08480}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature08480}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19838166}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19838166}, day = {29}, doi = {10.1038/nature08480}, issn = {1476-4687}, journal = {Nature}, keywords = {evolution}, month = {October}, number = {7268}, pages = {1243--1247}, posted-at = {2009-11-11 00:33:17}, priority = {2}, publisher = {Nature Publishing Group}, title = {Genome evolution and adaptation in a long-term experiment with Escherichia coli.}, url = {http://dx.doi.org/10.1038/nature08480}, volume = {461}, year = {2009} }

TY - JOUR ID - citeulike:5961524 L3 - citeulike-article-id:5961524 N2 - The relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentally evolving populations offers the opportunity to investigate this relationship with new precision. Here we sequence genomes sampled through 40,000 generations from a laboratory population of Escherichia coli. Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000 generations. Such clock-like regularity is usually viewed as the signature of neutral evolution, but several lines of evidence indicate that almost all of these mutations were beneficial. This same population later evolved an elevated mutation rate and accumulated hundreds of additional mutations dominated by a neutral signature. Thus, the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment. In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable. IS - 7268 JF - Nature SN - 1476-4687 EP - 1247 TI - Genome evolution and adaptation in a long-term experiment with Escherichia coli. PB - Nature Publishing Group VL - 461 SP - 1243 KW - evolution AU - Barrick, Jeffrey AU - Yu, Dong Su AU - Yoon, Sung Ho AU - Jeong, Haeyoung AU - Oh, Tae Kwang AU - Schneider, Dominique AU - Lenski, Richard AU - Kim, Jihyun PY - 2009/10/29/ UR - http://dx.doi.org/10.1038/nature08480 ER -