Transcranial Doppler ultrasonographic evaluation of cerebral circulation during passive tilting in patients with Parkinson's disease.

@article{citeulike:1649087, abstract = {PURPOSE: To assess the effects of the tilt test on cerebral blood flow velocity (CBFV), blood pressure, and heart rate in patients with Parkinson's disease (PD) without symptomatic orthostatic dysautonomia. METHODS: Thirty patients with idiopathic PD and 15 healthy controls were included. Mean middle cerebral artery blood flow velocity (CBFV) was recorded with transcranial Doppler sonography, while systolic (SBP), diastolic (DBP), and mean (MBP) blood pressure and heart rate were measured in the supine position and after passive tilting. RESULTS: There was no difference in resting SBP, DBP, or MBP between patients and controls. CBFV was lower at rest in patients than in controls and dropped significantly and similarly after tilting in both groups. SBP decreased in patients during the first 5 minutes of tilting (p < 0.05), whereas it increased progressively after the first minute in controls. In patients, DBP decreased slightly and MBP dropped during the first 2 minutes, then increased. Baseline heart rate was higher in patients than in controls (p < 0.05) and increased in both groups during tilting. CONCLUSION: Our results suggest that cardiovascular responses to tilting are delayed in PD patients and that subclinical autonomic dysfunction may be present even in the absence of symptomatic orthostatic dysautonomia.}, address = {Department of Neurology, Akdeniz University Faculty of Medicine, Arapsuyu 07059, Antalya, Turkey.}, author = {Mihci, E. and Dora, B. and Balkan, S.}, citeulike-article-id = {1649087}, doi = {10.1002/jcu.20309}, issn = {0091-2751}, journal = {J Clin Ultrasound}, keywords = {diagnosis, pd, ttt}, number = {3}, pages = {138--143}, posted-at = {2007-09-12 20:49:16}, priority = {2}, title = {Transcranial Doppler ultrasonographic evaluation of cerebral circulation during passive tilting in patients with Parkinson's disease.}, url = {http://dx.doi.org/10.1002/jcu.20309}, volume = {35}, year = {2007} }

TY - JOUR ID - citeulike:1649087 L3 - citeulike-article-id:1649087 N2 - PURPOSE: To assess the effects of the tilt test on cerebral blood flow velocity (CBFV), blood pressure, and heart rate in patients with Parkinson's disease (PD) without symptomatic orthostatic dysautonomia. METHODS: Thirty patients with idiopathic PD and 15 healthy controls were included. Mean middle cerebral artery blood flow velocity (CBFV) was recorded with transcranial Doppler sonography, while systolic (SBP), diastolic (DBP), and mean (MBP) blood pressure and heart rate were measured in the supine position and after passive tilting. RESULTS: There was no difference in resting SBP, DBP, or MBP between patients and controls. CBFV was lower at rest in patients than in controls and dropped significantly and similarly after tilting in both groups. SBP decreased in patients during the first 5 minutes of tilting (p < 0.05), whereas it increased progressively after the first minute in controls. In patients, DBP decreased slightly and MBP dropped during the first 2 minutes, then increased. Baseline heart rate was higher in patients than in controls (p < 0.05) and increased in both groups during tilting. CONCLUSION: Our results suggest that cardiovascular responses to tilting are delayed in PD patients and that subclinical autonomic dysfunction may be present even in the absence of symptomatic orthostatic dysautonomia. IS - 3 JF - J Clin Ultrasound SN - 0091-2751 AD - Department of Neurology, Akdeniz University Faculty of Medicine, Arapsuyu 07059, Antalya, Turkey. EP - 143 TI - Transcranial Doppler ultrasonographic evaluation of cerebral circulation during passive tilting in patients with Parkinson's disease. VL - 35 SP - 138 KW - diagnosis KW - pd KW - ttt AU - Mihci, E AU - Dora, B AU - Balkan, S PY - 2007///r UR - http://dx.doi.org/10.1002/jcu.20309 ER -