A toll-like receptor that prevents infection by uropathogenic bacteria.

@article{citeulike:380039, abstract = {Toll-like receptors (TLRs) recognize molecular patterns displayed by microorganisms, and their subsequent activation leads to the transcription of appropriate host-defense genes. Here we report the cloning and characterization of a member of the mammalian TLR family, TLR11, that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. Cells expressing TLR11 fail to respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. Mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating a potentially important role for TLR11 in preventing infection of internal organs of the urogenital system.}, address = {Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.}, author = {Zhang, D. and Zhang, G. and Hayden, M. S. and Greenblatt, M. B. and Bussey, C. and Flavell, R. A. and Ghosh, S. }, citeulike-article-id = {380039}, doi = {10.1126/science.1094351}, issn = {1095-9203}, journal = {Science}, keywords = {ecoli, tlr, uropathogenic}, month = {March}, number = {5663}, pages = {1522--1526}, posted-at = {2008-07-17 02:39:23}, priority = {2}, title = {A toll-like receptor that prevents infection by uropathogenic bacteria.}, url = {http://dx.doi.org/10.1126/science.1094351}, volume = {303}, year = {2004} }

TY - JOUR ID - citeulike:380039 L3 - citeulike-article-id:380039 TI - A toll-like receptor that prevents infection by uropathogenic bacteria. JF - Science VL - 303 IS - 5663 SP - 1522 EP - 1526 AD - Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. SN - 1095-9203 N2 - Toll-like receptors (TLRs) recognize molecular patterns displayed by microorganisms, and their subsequent activation leads to the transcription of appropriate host-defense genes. Here we report the cloning and characterization of a member of the mammalian TLR family, TLR11, that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. Cells expressing TLR11 fail to respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. Mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating a potentially important role for TLR11 in preventing infection of internal organs of the urogenital system. KW - ecoli KW - tlr KW - uropathogenic AU - Zhang, D AU - Zhang, G AU - Hayden, MS AU - Greenblatt, MB AU - Bussey, C AU - Flavell, RA AU - Ghosh, S PY - 2004/03/05/ UR - http://dx.doi.org/10.1126/science.1094351 ER -