The Thermodynamics of General Anesthesia Export

@article{citeulike:1325118, abstract = {It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton rule, which is based on free energy changes in the system and thus automatically incorporates the effects of melting point depression. This model accounts for the pressure reversal of anesthesia in a quantitative manner. Further, it explains why inflammation and the addition of divalent cations reduce the effectiveness of anesthesia. 10.1529/biophysj.106.099754}, author = {Heimburg, Thomas and Jackson, Andrew D.}, citeulike-article-id = {1325118}, citeulike-linkout-0 = {http://dx.doi.org/10.1529/biophysj.106.099754}, citeulike-linkout-1 = {http://www.biophysj.org/cgi/content/abstract/92/9/3159}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17293400}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17293400}, day = {1}, doi = {10.1529/biophysj.106.099754}, journal = {Biophys. J.}, keywords = {biology, cell-membrane}, month = {May}, number = {9}, pages = {3159--3165}, posted-at = {2007-05-24 14:29:17}, priority = {4}, title = {The Thermodynamics of General Anesthesia}, url = {http://dx.doi.org/10.1529/biophysj.106.099754}, volume = {92}, year = {2007} }

TY - JOUR ID - citeulike:1325118 L3 - citeulike-article-id:1325118 N2 - It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton rule, which is based on free energy changes in the system and thus automatically incorporates the effects of melting point depression. This model accounts for the pressure reversal of anesthesia in a quantitative manner. Further, it explains why inflammation and the addition of divalent cations reduce the effectiveness of anesthesia. 10.1529/biophysj.106.099754 IS - 9 JF - Biophys. J. EP - 3165 TI - The Thermodynamics of General Anesthesia VL - 92 SP - 3159 KW - biology KW - cell-membrane AU - Heimburg, Thomas AU - Jackson, Andrew PY - 2007/05/01/ UR - http://dx.doi.org/10.1529/biophysj.106.099754 ER -