Conservation of Regional Gene Expression in Mouse and Human Brain Export

@article{citeulike:1245949, abstract = {Author SummaryAnimal models of human neurodegenerative and psychiatric disorders, particularly mouse models, have assumed a central role in biomedical research aimed at discovering the causes of disease and generating novel, mechanism-based treatments. But to what degree can a mouse brain serve as a model for a human brain? Here we begin to address this question by looking at patterns of gene expression across three corresponding regions of mouse and human brains. We find that within each species, the different regions (motor cortex, striatum, and cerebellum) have very distinct gene expression profiles. It is likely that these differences reflect distinctions in regional neurochemistry and function. We then show that genes that are enriched in one of the three areas relative to the other two in mice have the same pattern of expression in humans. Looking at the relationship between conservation of expression and amino acid sequence, we find that genes showing patterned expression generally have been more conserved than more uniformly expressed genes. This suggests that in the brain, constraints on the evolution of DNA sequence and gene expression can also be particularly high for genes with regional or tissue-specific expression.}, author = {Strand, Andrew D. and Aragaki, Aaron K. and Baquet, Zachary C. and Hodges, Angela and Cunningham, Philip and Holmans, Peter and Jones, Kevin R. and Jones, Lesley and Kooperberg, Charles and Olson, James M.}, citeulike-article-id = {1245949}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.0030059}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17447843}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17447843}, day = {20}, doi = {10.1371/journal.pgen.0030059}, journal = {PLoS Genet}, keywords = {07, brain, conservation, cortex, express, gene\_, microarray, patterning, profile, ratio}, month = {April}, number = {4}, pages = {e59+}, posted-at = {2008-07-29 14:24:06}, priority = {2}, publisher = {Public Library of Science}, title = {Conservation of Regional Gene Expression in Mouse and Human Brain}, url = {http://dx.doi.org/10.1371/journal.pgen.0030059}, volume = {3}, year = {2007} }

TY - JOUR ID - citeulike:1245949 L3 - citeulike-article-id:1245949 N2 - Author SummaryAnimal models of human neurodegenerative and psychiatric disorders, particularly mouse models, have assumed a central role in biomedical research aimed at discovering the causes of disease and generating novel, mechanism-based treatments. But to what degree can a mouse brain serve as a model for a human brain? Here we begin to address this question by looking at patterns of gene expression across three corresponding regions of mouse and human brains. We find that within each species, the different regions (motor cortex, striatum, and cerebellum) have very distinct gene expression profiles. It is likely that these differences reflect distinctions in regional neurochemistry and function. We then show that genes that are enriched in one of the three areas relative to the other two in mice have the same pattern of expression in humans. Looking at the relationship between conservation of expression and amino acid sequence, we find that genes showing patterned expression generally have been more conserved than more uniformly expressed genes. This suggests that in the brain, constraints on the evolution of DNA sequence and gene expression can also be particularly high for genes with regional or tissue-specific expression. IS - 4 JF - PLoS Genet TI - Conservation of Regional Gene Expression in Mouse and Human Brain PB - Public Library of Science VL - 3 SP - e59 KW - 07 KW - brain KW - conservation KW - cortex KW - express KW - gene_ KW - microarray KW - patterning KW - profile KW - ratio AU - Strand, Andrew AU - Aragaki, Aaron AU - Baquet, Zachary AU - Hodges, Angela AU - Cunningham, Philip AU - Holmans, Peter AU - Jones, Kevin AU - Jones, Lesley AU - Kooperberg, Charles AU - Olson, James PY - 2007/04/20/ UR - http://dx.doi.org/10.1371/journal.pgen.0030059 ER -