Profiling gene expression using onto-express. Export

@article{citeulike:746935, abstract = {Gene expression profiles obtained through microarray or data mining analyses often exist as vast data strings. To interpret the biology of these genetic profiles, investigators must analyze this data in the context of other information such as the biological, biochemical, or molecular function of the translated proteins. This is particularly challenging for a human analyst because large quantities of less than relevant data often bury such information. To address this need we implemented an automated routine, called Onto-Express (http://vortex.cs.wayne.edu:8080), to systematically translate genetic fingerprints into functional profiles. Using strings of accession or cluster identification numbers, Onto-Express searches the public databases and returns tables that correlate expression profiles with the cytogenetic locations, biochemical and molecular functions, biological processes, cellular components, and cellular roles of the translated proteins. The profiles created by Onto-Express fundamentally increase the value of gene expression analyses by facilitating the translation of quantitative value sets to records that contain biological implications.}, address = {Department of Computer Science, Wayne State University School of Medicine, Detroit, MI, 48201, USA.}, author = {Khatri, P. and Draghici, S. and Ostermeier, G. C. and Krawetz, S. A.}, citeulike-article-id = {746935}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/geno.2002.6698}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0888-7543(02)96698-X}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11829497}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11829497}, doi = {10.1006/geno.2002.6698}, issn = {0888-7543}, journal = {Genomics}, keywords = {02, express}, month = {February}, number = {2}, pages = {266--270}, posted-at = {2008-07-22 14:35:56}, priority = {2}, title = {Profiling gene expression using onto-express.}, url = {http://dx.doi.org/10.1006/geno.2002.6698}, volume = {79}, year = {2002} }

TY - JOUR ID - citeulike:746935 L3 - citeulike-article-id:746935 N2 - Gene expression profiles obtained through microarray or data mining analyses often exist as vast data strings. To interpret the biology of these genetic profiles, investigators must analyze this data in the context of other information such as the biological, biochemical, or molecular function of the translated proteins. This is particularly challenging for a human analyst because large quantities of less than relevant data often bury such information. To address this need we implemented an automated routine, called Onto-Express (http://vortex.cs.wayne.edu:8080), to systematically translate genetic fingerprints into functional profiles. Using strings of accession or cluster identification numbers, Onto-Express searches the public databases and returns tables that correlate expression profiles with the cytogenetic locations, biochemical and molecular functions, biological processes, cellular components, and cellular roles of the translated proteins. The profiles created by Onto-Express fundamentally increase the value of gene expression analyses by facilitating the translation of quantitative value sets to records that contain biological implications. IS - 2 JF - Genomics SN - 0888-7543 AD - Department of Computer Science, Wayne State University School of Medicine, Detroit, MI, 48201, USA. EP - 270 TI - Profiling gene expression using onto-express. VL - 79 SP - 266 KW - 02 KW - express AU - Khatri, P AU - Draghici, S AU - Ostermeier, GC AU - Krawetz, SA PY - 2002/02// UR - http://dx.doi.org/10.1006/geno.2002.6698 ER -