Control over conflict during movement preparation: role of posterior parietal cortex. Export

@article{citeulike:2667677, abstract = {Flexible behavior in humans often requires that rapid choices be made between conflicting action plans. Although much attention has focused on prefrontal regions, little is understood about the contribution of parietal cortex under situations of response conflict. Here we show that right parietal damage associated with spatial neglect leads to paradoxical facilitation (speeding) of rightward movements in the presence of conflicting leftward response plans. These findings indicate a critical role for parietal regions in action planning when there is response competition. In contrast, patients with prefrontal damage have an augmented cost of conflict for both leftward and rightward movements. The results suggest involvement of two independent systems in situations of response conflict, with right parietal cortex being a crucial site for automatic activation of competing motor plans and prefrontal regions acting independently to inhibit action plans irrelevant to current task goals.}, address = {Institute of Cognitive Neuroscience and Institute of Neurology, University College London, London WC1N 3AR, UK.}, author = {Coulthard, E. J. and Nachev, P. and Husain, M.}, citeulike-article-id = {2667677}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2008.02.009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18400170}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18400170}, comment = {* Examination of behavior under conflicting action plans in patients with post-stroke right parietal neglect * Employs Eriksen flanker task, finds that R parietal damage leads to facilitation of rightward movements (decreased RTs) in the presence of conflicting leftward response plans, as governed by flanker cues * In particular the authors emphasize that while right parietal damage and accompanying loss of leftward motor plans should eliminate the increase in RTs seen under response conflict in normal subjects, this alone does not explain faster responses * The authors suggest two independent systems operating during conflict: a parietal region representing competing motor plans, and a prefrontal region inhibiting inappropriate motor plans}, day = {10}, doi = {10.1016/j.neuron.2008.02.009}, issn = {1097-4199}, journal = {Neuron}, keywords = {conflict, eriksen\_flanker\_task, human, lesion, neglect, parietal, prefrontal, response\_inhibition, stroke}, month = {April}, number = {1}, pages = {144--157}, posted-at = {2008-07-07 18:08:13}, priority = {2}, title = {Control over conflict during movement preparation: role of posterior parietal cortex.}, url = {http://dx.doi.org/10.1016/j.neuron.2008.02.009}, volume = {58}, year = {2008} }

TY - JOUR ID - citeulike:2667677 L3 - citeulike-article-id:2667677 N2 - Flexible behavior in humans often requires that rapid choices be made between conflicting action plans. Although much attention has focused on prefrontal regions, little is understood about the contribution of parietal cortex under situations of response conflict. Here we show that right parietal damage associated with spatial neglect leads to paradoxical facilitation (speeding) of rightward movements in the presence of conflicting leftward response plans. These findings indicate a critical role for parietal regions in action planning when there is response competition. In contrast, patients with prefrontal damage have an augmented cost of conflict for both leftward and rightward movements. The results suggest involvement of two independent systems in situations of response conflict, with right parietal cortex being a crucial site for automatic activation of competing motor plans and prefrontal regions acting independently to inhibit action plans irrelevant to current task goals. IS - 1 JF - Neuron SN - 1097-4199 AD - Institute of Cognitive Neuroscience and Institute of Neurology, University College London, London WC1N 3AR, UK. EP - 157 TI - Control over conflict during movement preparation: role of posterior parietal cortex. VL - 58 SP - 144 KW - conflict KW - eriksen_flanker_task KW - human KW - lesion KW - neglect KW - parietal KW - prefrontal KW - response_inhibition KW - stroke N1 - * Examination of behavior under conflicting action plans in patients with post-stroke right parietal neglect * Employs Eriksen flanker task, finds that R parietal damage leads to facilitation of rightward movements (decreased RTs) in the presence of conflicting leftward response plans, as governed by flanker cues * In particular the authors emphasize that while right parietal damage and accompanying loss of leftward motor plans should eliminate the increase in RTs seen under response conflict in normal subjects, this alone does not explain faster responses * The authors suggest two independent systems operating during conflict: a parietal region representing competing motor plans, and a prefrontal region inhibiting inappropriate motor plans AU - Coulthard, EJ AU - Nachev, P AU - Husain, M PY - 2008/04/10/ UR - http://dx.doi.org/10.1016/j.neuron.2008.02.009 ER -