Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events. Export

@article{citeulike:4842453, abstract = {The basal ganglia network is divided into two functionally related subsystems: the neuromodulators and the main axis. It is assumed that neuromodulators adjust cortico-striatal coupling. This adjustment might depend on the response properties and temporal interactions between neuromodulators. We studied functional interactions between simultaneously recorded pairs of neurons in the basal ganglia while monkeys performed a classical conditioning task that included rewarding, neutral, and aversive events. Neurons that belong to a single neuromodulator group exhibited similar average responses, whereas main axis neurons responded in a highly diverse manner. Dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. These changes in functional connectivity occurred at different epochs of the trial. Thus, the coding scheme of neuromodulators (but not main axis neurons) can be viewed as a single-dimensional code that is further enriched by dynamic neuronal interactions.}, author = {Joshua, Mati and Adler, Avital and Prut, Yifat and Vaadia, Eilon and Wickens, Jeffery R. and Bergman, Hagai}, citeulike-article-id = {4842453}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2009.04.026}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S089662730900350X}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19524528}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19524528}, day = {11}, doi = {10.1016/j.neuron.2009.04.026}, issn = {1097-4199}, journal = {Neuron}, keywords = {basal\_ganglia, classical\_conditioning, dopamine, monkey, neurophysiology, reinforcement\_learning, reward, synchrony}, month = {June}, number = {5}, pages = {695--704}, posted-at = {2009-08-10 15:09:04}, priority = {2}, title = {Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events.}, url = {http://dx.doi.org/10.1016/j.neuron.2009.04.026}, volume = {62}, year = {2009} }

TY - JOUR ID - citeulike:4842453 L3 - citeulike-article-id:4842453 N2 - The basal ganglia network is divided into two functionally related subsystems: the neuromodulators and the main axis. It is assumed that neuromodulators adjust cortico-striatal coupling. This adjustment might depend on the response properties and temporal interactions between neuromodulators. We studied functional interactions between simultaneously recorded pairs of neurons in the basal ganglia while monkeys performed a classical conditioning task that included rewarding, neutral, and aversive events. Neurons that belong to a single neuromodulator group exhibited similar average responses, whereas main axis neurons responded in a highly diverse manner. Dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. These changes in functional connectivity occurred at different epochs of the trial. Thus, the coding scheme of neuromodulators (but not main axis neurons) can be viewed as a single-dimensional code that is further enriched by dynamic neuronal interactions. IS - 5 JF - Neuron SN - 1097-4199 EP - 704 TI - Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events. VL - 62 SP - 695 KW - basal_ganglia KW - classical_conditioning KW - dopamine KW - monkey KW - neurophysiology KW - reinforcement_learning KW - reward KW - synchrony AU - Joshua, Mati AU - Adler, Avital AU - Prut, Yifat AU - Vaadia, Eilon AU - Wickens, Jeffery AU - Bergman, Hagai PY - 2009/06/11/ UR - http://dx.doi.org/10.1016/j.neuron.2009.04.026 ER -