Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Export

@article{citeulike:802942, abstract = {MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on death and disability after head injury. We randomly allocated 10,008 adults with head injury and a Glasgow Coma Scale score of 14 or less, within 8 h of injury, to a 48-h infusion of corticosteroid (methylprednisolone) or placebo. Data at 6 months were obtained for 9673 (96.7\%) patients. The risk of death was higher in the corticosteroid group than in the placebo group (1248 [25.7\%] vs 1075 [22.3\%] deaths; relative risk 1.15, 95\% CI 1.07-1.24; p=0.0001), as was the risk of death or severe disability (1828 [38.1\%] vs 1728 [36.3\%] dead or severely disabled; 1.05, 0.99-1.10; p=0.079). There was no evidence that the effect of corticosteroids differed by injury severity or time since injury. These results lend support to our earlier conclusion that corticosteroids should not be used routinely in the treatment of head injury.}, author = {Edwards, P. and Arango, M. and Balica, L. and Cottingham, R. and El-Sayed, H. and Farrell, B. and Fernandes, J. and Gogichaisvili, T. and Golden, N. and Hartzenberg, B. and Husain, M. and Ulloa, M. I. and Jerbi, Z. and Khamis, H. and Komolafe, E. and Lalo\"{e}, V. and Lomas, G. and Ludwig, S. and Mazairac, G. and Mu\~{n}oz Sanch\'{e}z, M. d. e. . L. and Nasi, L. and Olldashi, F. and Plunkett, P. and Roberts, I. and Sandercock, P. and Shakur, H. and Soler, C. and Stocker, R. and Svoboda, P. and Trenkler, S. and Venkataramana, N. K. and Wasserberg, J. and Yates, D. and Yutthakasemsunt, S. and {}}, citeulike-article-id = {802942}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0140-6736(05)66552-X}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15936423}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15936423}, doi = {10.1016/S0140-6736(05)66552-X}, issn = {1474-547X}, journal = {Lancet}, keywords = {clinical\_trial, corticosteroids, head\_injury, medicine}, number = {9475}, pages = {1957--1959}, posted-at = {2006-08-16 20:33:13}, priority = {2}, title = {Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months.}, url = {http://dx.doi.org/10.1016/S0140-6736(05)66552-X}, volume = {365}, year = {2005} }

TY - JOUR ID - citeulike:802942 L3 - citeulike-article-id:802942 N2 - MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on death and disability after head injury. We randomly allocated 10,008 adults with head injury and a Glasgow Coma Scale score of 14 or less, within 8 h of injury, to a 48-h infusion of corticosteroid (methylprednisolone) or placebo. Data at 6 months were obtained for 9673 (96.7%) patients. The risk of death was higher in the corticosteroid group than in the placebo group (1248 [25.7%] vs 1075 [22.3%] deaths; relative risk 1.15, 95% CI 1.07-1.24; p=0.0001), as was the risk of death or severe disability (1828 [38.1%] vs 1728 [36.3%] dead or severely disabled; 1.05, 0.99-1.10; p=0.079). There was no evidence that the effect of corticosteroids differed by injury severity or time since injury. These results lend support to our earlier conclusion that corticosteroids should not be used routinely in the treatment of head injury. IS - 9475 JF - Lancet SN - 1474-547X EP - 1959 TI - Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. VL - 365 SP - 1957 KW - clinical_trial KW - corticosteroids KW - head_injury KW - medicine AU - Edwards, P AU - Arango, M AU - Balica, L AU - Cottingham, R AU - El-Sayed, H AU - Farrell, B AU - Fernandes, J AU - Gogichaisvili, T AU - Golden, N AU - Hartzenberg, B AU - Husain, M AU - Ulloa, MI AU - Jerbi, Z AU - Khamis, H AU - Komolafe, E AU - Laloë, V AU - Lomas, G AU - Ludwig, S AU - Mazairac, G AU - Muñoz Sanchéz, Mde L AU - Nasi, L AU - Olldashi, F AU - Plunkett, P AU - Roberts, I AU - Sandercock, P AU - Shakur, H AU - Soler, C AU - Stocker, R AU - Svoboda, P AU - Trenkler, S AU - Venkataramana, NK AU - Wasserberg, J AU - Yates, D AU - Yutthakasemsunt, S PY - 2005///0 UR - http://dx.doi.org/10.1016/S0140-6736(05)66552-X ER -