Current animal models of obsessive compulsive disorder: A critical review Export

@article{citeulike:4879933, abstract = {During the last 30 years there have been many attempts to develop animal models of obsessive compulsive disorder (OCD), in the hope that they may provide a route for furthering our understanding and treatment of this disorder. The present paper reviews current genetic, pharmacological and behavioral animal models of OCD, and evaluates their face validity (derived from phenomenological similarity between the behavior in the animal model and the specific symptoms of the human condition), predictive validity (derived from similarity in response to treatment) and construct validity (derived from similarity in the underlying mechanisms—physiological or psychological).}, author = {Joel, D.}, citeulike-article-id = {4879933}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.pnpbp.2005.11.006}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0278584605003507}, doi = {10.1016/j.pnpbp.2005.11.006}, issn = {02785846}, journal = {Progress in Neuro-Psychopharmacology and Biological Psychiatry}, keywords = {animal-model, ocd, psychiatry, review}, month = {May}, number = {3}, pages = {374--388}, posted-at = {2009-06-17 13:13:23}, priority = {2}, title = {Current animal models of obsessive compulsive disorder: A critical review}, url = {http://dx.doi.org/10.1016/j.pnpbp.2005.11.006}, volume = {30}, year = {2006} }

TY - JOUR ID - citeulike:4879933 L3 - citeulike-article-id:4879933 N2 - During the last 30 years there have been many attempts to develop animal models of obsessive compulsive disorder (OCD), in the hope that they may provide a route for furthering our understanding and treatment of this disorder. The present paper reviews current genetic, pharmacological and behavioral animal models of OCD, and evaluates their face validity (derived from phenomenological similarity between the behavior in the animal model and the specific symptoms of the human condition), predictive validity (derived from similarity in response to treatment) and construct validity (derived from similarity in the underlying mechanisms—physiological or psychological). IS - 3 JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry SN - 02785846 EP - 388 TI - Current animal models of obsessive compulsive disorder: A critical review VL - 30 SP - 374 KW - animal-model KW - ocd KW - psychiatry KW - review AU - Joel, D PY - 2006/05// UR - http://dx.doi.org/10.1016/j.pnpbp.2005.11.006 ER -