Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity Export

@article{citeulike:5842958, abstract = {10.1073/pnas.0903183106 Variations in people's vulnerability to stressful life events may rise from a predated neural sensitivity as well as from differential neural modifications in response to the event. Because the occurrence of a stressful life event cannot be foreseen, characterizing the temporal trajectory of its neural manifestations in humans has been a real challenge. The current prospective study examined the emotional experience and brain responses of 50 a priori healthy new recruits to the Israeli Defense Forces at 2 time points: before they entered their mandatory military service and after their subsequent exposure to stressful events while deployed in combat units. Over time, soldiers reported on increase in stress symptoms that was correlated with greater amygdala and hippocampus responsiveness to stress-related content. However, these closely situated core limbic regions exhibited different temporal trajectories with regard to the stress effect; whereas amygdala's reactivity before stress predicted the increase in stress symptoms, the hippocampal change in activation over time correlated with the increase in such symptoms. Hippocampal plasticity was also reflected by a modification over time of its functional coupling with the ventromedial prefrontal cortex, and this coupling magnitude was again predicted by predated amygdala reactivity. Together, these findings suggest that variations in human's likelihood to develop symptomatic phenomena following stressful life events may depend on a balanced interplay between their amygdala's predisposing reactivity and hippocampal posteriori intra- and interregional plasticity. Accordingly, an individually tailored therapeutic approach for trauma survivors should target these 2 neural probes while considering their unique temporal prints.}, author = {Admon, Roee and Lubin, Gad and Stern, Orit and Rosenberg, Keren and Sela, Lee and Ben-Ami, Haim and Hendler, Talma}, citeulike-article-id = {5842958}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0903183106}, citeulike-linkout-1 = {http://www.pnas.org/content/106/33/14120.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/106/33/14120.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19666562}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19666562}, day = {18}, doi = {10.1073/pnas.0903183106}, journal = {Proceedings of the National Academy of Sciences}, keywords = {amygdala, fmri, prospective\_study, ptsd}, month = {August}, number = {33}, pages = {14120--14125}, posted-at = {2009-09-26 14:04:39}, priority = {2}, title = {Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity}, url = {http://dx.doi.org/10.1073/pnas.0903183106}, volume = {106}, year = {2009} }

TY - JOUR ID - citeulike:5842958 L3 - citeulike-article-id:5842958 N2 - 10.1073/pnas.0903183106 Variations in people's vulnerability to stressful life events may rise from a predated neural sensitivity as well as from differential neural modifications in response to the event. Because the occurrence of a stressful life event cannot be foreseen, characterizing the temporal trajectory of its neural manifestations in humans has been a real challenge. The current prospective study examined the emotional experience and brain responses of 50 a priori healthy new recruits to the Israeli Defense Forces at 2 time points: before they entered their mandatory military service and after their subsequent exposure to stressful events while deployed in combat units. Over time, soldiers reported on increase in stress symptoms that was correlated with greater amygdala and hippocampus responsiveness to stress-related content. However, these closely situated core limbic regions exhibited different temporal trajectories with regard to the stress effect; whereas amygdala's reactivity before stress predicted the increase in stress symptoms, the hippocampal change in activation over time correlated with the increase in such symptoms. Hippocampal plasticity was also reflected by a modification over time of its functional coupling with the ventromedial prefrontal cortex, and this coupling magnitude was again predicted by predated amygdala reactivity. Together, these findings suggest that variations in human's likelihood to develop symptomatic phenomena following stressful life events may depend on a balanced interplay between their amygdala's predisposing reactivity and hippocampal posteriori intra- and interregional plasticity. Accordingly, an individually tailored therapeutic approach for trauma survivors should target these 2 neural probes while considering their unique temporal prints. IS - 33 JF - Proceedings of the National Academy of Sciences EP - 14125 TI - Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity VL - 106 SP - 14120 KW - amygdala KW - fmri KW - prospective_study KW - ptsd AU - Admon, Roee AU - Lubin, Gad AU - Stern, Orit AU - Rosenberg, Keren AU - Sela, Lee AU - Ben-Ami, Haim AU - Hendler, Talma PY - 2009/08/18/ UR - http://dx.doi.org/10.1073/pnas.0903183106 ER -