Submicrometer intracellular chemical optical fiber sensors

by: W Tan, Zy Shi, S Smith, D Birnbaum, R Kopelman

Science, Vol. 258, No. 5083. (30 October 1992), pp. 778-781.

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Abstract

A thousandfold miniaturization of immobilized optical fiber sensors, a millionfold or more sample reduction, and at least a hundredfold shorter response time, all simultaneously, were achieved by combining nanofabricated optical fiber tips with near-field photopolymerization. Specifically, pH optical fiber sensors were prepared with internal calibration, making use of the differences in both fluorescence and absorption of the acidic and basic dye species. The submicrometer sensors have excellent detection limits, as well as photostability, reversibility, and millisecond response times. Successful applications include intracellular and intraembryonic measurements. Potential applications include spatially and temporally resolved chemical analysis and kinetics inside single biological cells and their substructures. 10.1126/science.1439785

@article{citeulike:1569838, abstract = {A thousandfold miniaturization of immobilized optical fiber sensors, a millionfold or more sample reduction, and at least a hundredfold shorter response time, all simultaneously, were achieved by combining nanofabricated optical fiber tips with near-field photopolymerization. Specifically, pH optical fiber sensors were prepared with internal calibration, making use of the differences in both fluorescence and absorption of the acidic and basic dye species. The submicrometer sensors have excellent detection limits, as well as photostability, reversibility, and millisecond response times. Successful applications include intracellular and intraembryonic measurements. Potential applications include spatially and temporally resolved chemical analysis and kinetics inside single biological cells and their substructures. 10.1126/science.1439785}, author = {Tan, W. and Shi, Zy and Smith, S. and Birnbaum, D. and Kopelman, R. }, citeulike-article-id = {1569838}, doi = {http://dx.doi.org/10.1126/science.1439785}, journal = {Science}, keywords = {281}, month = {October}, number = {5083}, pages = {778--781}, posted-at = {2007-08-16 19:01:30}, priority = {2}, title = {Submicrometer intracellular chemical optical fiber sensors}, url = {http://dx.doi.org/10.1126/science.1439785}, volume = {258}, year = {1992} }

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TY - JOUR ID - citeulike:1569838 L3 - citeulike-article-id:1569838 TI - Submicrometer intracellular chemical optical fiber sensors JF - Science VL - 258 IS - 5083 SP - 778 EP - 781 N2 - A thousandfold miniaturization of immobilized optical fiber sensors, a millionfold or more sample reduction, and at least a hundredfold shorter response time, all simultaneously, were achieved by combining nanofabricated optical fiber tips with near-field photopolymerization. Specifically, pH optical fiber sensors were prepared with internal calibration, making use of the differences in both fluorescence and absorption of the acidic and basic dye species. The submicrometer sensors have excellent detection limits, as well as photostability, reversibility, and millisecond response times. Successful applications include intracellular and intraembryonic measurements. Potential applications include spatially and temporally resolved chemical analysis and kinetics inside single biological cells and their substructures. 10.1126/science.1439785 KW - 281 AU - Tan, W AU - Shi, Zy AU - Smith, S AU - Birnbaum, D AU - Kopelman, R PY - 1992/10/30/ UR - http://dx.doi.org/10.1126/science.1439785 ER -

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