Neuronal Competition and Selection During Memory Formation Export

@article{citeulike:1239817, abstract = {Competition between neurons is necessary for refining neural circuits during development and may be important for selecting the neurons that participate in encoding memories in the adult brain. To examine neuronal competition during memory formation, we conducted experiments with mice in which we manipulated the function of CREB (adenosine 3',5'-monophosphate response element-binding protein) in subsets of neurons. Changes in CREB function influenced the probability that individual lateral amygdala neurons were recruited into a fear memory trace. Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning. 10.1126/science.1139438}, author = {Han, Jin-Hee and Kushner, Steven A. and Yiu, Adelaide P. and Cole, Christy J. and Matynia, Anna and Brown, Robert A. and Neve, Rachael L. and Guzowski, John F. and Silva, Alcino J. and Josselyn, Sheena A.}, citeulike-article-id = {1239817}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1139438}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/316/5823/457}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17446403}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17446403}, day = {20}, doi = {10.1126/science.1139438}, journal = {Science}, keywords = {binding\_protein, creb, memories, memory\_formation, probability, response\_element}, month = {April}, number = {5823}, pages = {457--460}, posted-at = {2009-10-31 18:41:46}, priority = {2}, title = {Neuronal Competition and Selection During Memory Formation}, url = {http://dx.doi.org/10.1126/science.1139438}, volume = {316}, year = {2007} }

TY - JOUR ID - citeulike:1239817 L3 - citeulike-article-id:1239817 N2 - Competition between neurons is necessary for refining neural circuits during development and may be important for selecting the neurons that participate in encoding memories in the adult brain. To examine neuronal competition during memory formation, we conducted experiments with mice in which we manipulated the function of CREB (adenosine 3',5'-monophosphate response element-binding protein) in subsets of neurons. Changes in CREB function influenced the probability that individual lateral amygdala neurons were recruited into a fear memory trace. Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning. 10.1126/science.1139438 IS - 5823 JF - Science EP - 460 TI - Neuronal Competition and Selection During Memory Formation VL - 316 SP - 457 KW - binding_protein KW - creb KW - memories KW - memory_formation KW - probability KW - response_element AU - Han, Jin-Hee AU - Kushner, Steven AU - Yiu, Adelaide AU - Cole, Christy AU - Matynia, Anna AU - Brown, Robert AU - Neve, Rachael AU - Guzowski, John AU - Silva, Alcino AU - Josselyn, Sheena PY - 2007/04/20/ UR - http://dx.doi.org/10.1126/science.1139438 ER -