Mitochondrial defects in cancer Export

@article{citeulike:1960367, abstract = {Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional consequences in cancer development, and therapeutic implications.}, author = {Carew, Jennifer and Huang, Peng}, citeulike-article-id = {1960367}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1476-4598-1-9}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12513701}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12513701}, doi = {10.1186/1476-4598-1-9}, journal = {Molecular Cancer}, keywords = {cancer, mitochondria, ros}, number = {1}, posted-at = {2007-11-22 17:38:31}, priority = {5}, title = {Mitochondrial defects in cancer}, url = {http://dx.doi.org/10.1186/1476-4598-1-9}, volume = {1}, year = {2002} }

TY - JOUR ID - citeulike:1960367 L3 - citeulike-article-id:1960367 N2 - Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional consequences in cancer development, and therapeutic implications. IS - 1 JF - Molecular Cancer TI - Mitochondrial defects in cancer VL - 1 KW - cancer KW - mitochondria KW - ros AU - Carew, Jennifer AU - Huang, Peng PY - 2002/// UR - http://dx.doi.org/10.1186/1476-4598-1-9 ER -