Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle Export

@article{citeulike:2235558, abstract = {Mitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified, understanding their functional interrelationships has been a challenge. Here we construct a comprehensive network of the mitochondrial system. We integrated genome-wide datasets to generate an accurate and inclusive mitochondrial parts list. Together with benchmarked measures of protein interactions, a network of mitochondria was constructed in their cellular context, including extra-mitochondrial proteins. This network also integrates data from different organisms to expand the known mitochondrial biology beyond the information in the existing databases. Our network brings together annotated and predicted functions into a single framework. This enabled, for the entire system, a survey of mutant phenotypes, gene regulation, evolution, and disease susceptibility. Furthermore, we experimentally validated the localization of several candidate proteins and derived novel functional contexts for hundreds of uncharacterized proteins. Our network thus advances the understanding of the mitochondrial system in yeast and identifies properties of genes underlying human mitochondrial disorders.}, author = {Perocchi, Fabiana and Jensen, Lars J. and Gagneur, Julien and Ahting, Uwe and von Mering, Christian and Bork, Peer and Prokisch, Holger and Steinmetz, Lars M.}, citeulike-article-id = {2235558}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.0020170}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17054397}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17054397}, day = {1}, doi = {10.1371/journal.pgen.0020170}, journal = {PLoS Genetics}, keywords = {mitochondria, modules, ppi, proteome, yeast}, month = {October}, number = {10}, pages = {e170+}, posted-at = {2008-01-15 17:14:29}, priority = {5}, title = {Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle}, url = {http://dx.doi.org/10.1371/journal.pgen.0020170}, volume = {2}, year = {2006} }

TY - JOUR ID - citeulike:2235558 L3 - citeulike-article-id:2235558 N2 - Mitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified, understanding their functional interrelationships has been a challenge. Here we construct a comprehensive network of the mitochondrial system. We integrated genome-wide datasets to generate an accurate and inclusive mitochondrial parts list. Together with benchmarked measures of protein interactions, a network of mitochondria was constructed in their cellular context, including extra-mitochondrial proteins. This network also integrates data from different organisms to expand the known mitochondrial biology beyond the information in the existing databases. Our network brings together annotated and predicted functions into a single framework. This enabled, for the entire system, a survey of mutant phenotypes, gene regulation, evolution, and disease susceptibility. Furthermore, we experimentally validated the localization of several candidate proteins and derived novel functional contexts for hundreds of uncharacterized proteins. Our network thus advances the understanding of the mitochondrial system in yeast and identifies properties of genes underlying human mitochondrial disorders. IS - 10 JF - PLoS Genetics TI - Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle VL - 2 SP - e170 KW - mitochondria KW - modules KW - ppi KW - proteome KW - yeast AU - Perocchi, Fabiana AU - Jensen, Lars AU - Gagneur, Julien AU - Ahting, Uwe AU - von Mering, Christian AU - Bork, Peer AU - Prokisch, Holger AU - Steinmetz, Lars PY - 2006/10/01/ UR - http://dx.doi.org/10.1371/journal.pgen.0020170 ER -