Beyond the evolutionary theory of ageing, from functional genomics to evo-gero. Export

@article{citeulike:2799652, abstract = {By the mid 1970s, the mechanisms by which ageing can evolve had a secure theoretical basis in population genetics. Here, we discuss how subsequent evolutionary work has focussed on testing and extending this theory, and on attempting to integrate it with other emerging facets of the biology of ageing, such as genetic studies of long-lived mutants and of phenotypic plasticity in ageing, such as in response to nutritional status. We also describe how functional genomic studies are providing new insights into the evolutionary forces shaping genome evolution and lifespan control. Future challenges include understanding the biochemistry of longevity and how its failure generates ageing and associated diseases, and the determination of the genetic basis of lifespan evolution and the great plasticity that it displays.}, address = {Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. l.partridge@ucl.ac.uk}, author = {Partridge, L. and Gems, D.}, citeulike-article-id = {2799652}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tree.2006.02.008}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0169534706000826}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16769434}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16769434}, doi = {10.1016/j.tree.2006.02.008}, issn = {0169-5347}, journal = {Trends in ecology \& evolution (Personal edition)}, keywords = {aging, evolution, genomics}, month = {June}, number = {6}, pages = {334--340}, posted-at = {2008-05-14 18:19:18}, priority = {5}, title = {Beyond the evolutionary theory of ageing, from functional genomics to evo-gero.}, url = {http://dx.doi.org/10.1016/j.tree.2006.02.008}, volume = {21}, year = {2006} }

TY - JOUR ID - citeulike:2799652 L3 - citeulike-article-id:2799652 N2 - By the mid 1970s, the mechanisms by which ageing can evolve had a secure theoretical basis in population genetics. Here, we discuss how subsequent evolutionary work has focussed on testing and extending this theory, and on attempting to integrate it with other emerging facets of the biology of ageing, such as genetic studies of long-lived mutants and of phenotypic plasticity in ageing, such as in response to nutritional status. We also describe how functional genomic studies are providing new insights into the evolutionary forces shaping genome evolution and lifespan control. Future challenges include understanding the biochemistry of longevity and how its failure generates ageing and associated diseases, and the determination of the genetic basis of lifespan evolution and the great plasticity that it displays. IS - 6 JF - Trends in ecology & evolution (Personal edition) SN - 0169-5347 AD - Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK. l.partridge@ucl.ac.uk EP - 340 TI - Beyond the evolutionary theory of ageing, from functional genomics to evo-gero. VL - 21 SP - 334 KW - aging KW - evolution KW - genomics AU - Partridge, L AU - Gems, D PY - 2006/06// UR - http://dx.doi.org/10.1016/j.tree.2006.02.008 ER -