Single virus detection from the reactive shift of a whispering-gallery mode Export

@article{citeulike:3854441, abstract = {10.1073/pnas.0808988106 We report the label-free, real-time optical detection of Influenza A virus particles. Binding of single virions is observed from discrete changes in the resonance frequency/wavelength of a whispering-gallery mode excited in a microspherical cavity. We find that the magnitude of the discrete wavelength-shift signal can be sufficiently enhanced by reducing the microsphere size. A reactive sensing mechanism with inverse dependence on mode volume is confirmed in experiments with virus-sized polystyrene nanoparticles. By comparing the electromagnetic theory for this reactive effect with experiments, the size and mass (≈5.2 × 10 g) of a bound virion are determined directly from the optimal resonance shift.}, author = {Vollmer, F. and Arnold, S. and Keng, D.}, citeulike-article-id = {3854441}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0808988106}, citeulike-linkout-1 = {http://www.pnas.org/content/105/52/20701.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/105/52/20701.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19075225}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19075225}, day = {30}, doi = {10.1073/pnas.0808988106}, journal = {Proceedings of the National Academy of Sciences}, keywords = {biosensor, cavity\_resonator, mems, optics, spherical\_resonator, thesis\_prevwork, virus}, month = {December}, number = {52}, pages = {20701--20704}, posted-at = {2009-01-16 10:34:33}, priority = {4}, title = {Single virus detection from the reactive shift of a whispering-gallery mode}, url = {http://dx.doi.org/10.1073/pnas.0808988106}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3854441 L3 - citeulike-article-id:3854441 N2 - 10.1073/pnas.0808988106 We report the label-free, real-time optical detection of Influenza A virus particles. Binding of single virions is observed from discrete changes in the resonance frequency/wavelength of a whispering-gallery mode excited in a microspherical cavity. We find that the magnitude of the discrete wavelength-shift signal can be sufficiently enhanced by reducing the microsphere size. A reactive sensing mechanism with inverse dependence on mode volume is confirmed in experiments with virus-sized polystyrene nanoparticles. By comparing the electromagnetic theory for this reactive effect with experiments, the size and mass (≈5.2 × 10 g) of a bound virion are determined directly from the optimal resonance shift. IS - 52 JF - Proceedings of the National Academy of Sciences EP - 20704 TI - Single virus detection from the reactive shift of a whispering-gallery mode VL - 105 SP - 20701 KW - biosensor KW - cavity_resonator KW - mems KW - optics KW - spherical_resonator KW - thesis_prevwork KW - virus AU - Vollmer, F AU - Arnold, S AU - Keng, D PY - 2008/12/30/ UR - http://dx.doi.org/10.1073/pnas.0808988106 ER -