Shift of whispering-gallery modes in microspheres by protein adsorption Export

@article{citeulike:3872331, abstract = {Biosensors based on the shift of whispering-gallery modes in microspheres accompanying protein adsorption are described by use of a perturbation theory. For random spatial adsorption, theory predicts that the shift should be inversely proportional to microsphere radius R and proportional to protein surface density and excess polarizability. Measurements are found to be consistent with the theory, and the correspondence enables the average surface area occupied by a single protein to be estimated. These results are consistent with crystallographic data for bovine serum albumin. The theoretical shift for adsorption of a single protein is found to be extremely sensitive to the target region, with adsorption in the most sensitive region varying as 1/R5/2 . Specific parameters for single protein or virus particle detection are predicted.}, author = {Arnold, S. and Khoshsima, M. and Teraoka, I. and Holler, S. and Vollmer, F.}, citeulike-article-id = {3872331}, citeulike-linkout-0 = {http://dx.doi.org/10.1364/OL.28.000272}, citeulike-linkout-1 = {http://www.opticsinfobase.org/abstract.cfm?id=71259}, day = {15}, doi = {10.1364/OL.28.000272}, journal = {Opt. Lett.}, keywords = {biosensor, cavity\_resonator, experiment, protein, resonant\_sensor, spherical\_resonator}, month = {February}, number = {4}, pages = {272--274}, posted-at = {2009-05-09 15:20:47}, priority = {2}, publisher = {OSA}, title = {Shift of whispering-gallery modes in microspheres by protein adsorption}, url = {http://dx.doi.org/10.1364/OL.28.000272}, volume = {28}, year = {2003} }

TY - JOUR ID - citeulike:3872331 L3 - citeulike-article-id:3872331 N2 - Biosensors based on the shift of whispering-gallery modes in microspheres accompanying protein adsorption are described by use of a perturbation theory. For random spatial adsorption, theory predicts that the shift should be inversely proportional to microsphere radius R and proportional to protein surface density and excess polarizability. Measurements are found to be consistent with the theory, and the correspondence enables the average surface area occupied by a single protein to be estimated. These results are consistent with crystallographic data for bovine serum albumin. The theoretical shift for adsorption of a single protein is found to be extremely sensitive to the target region, with adsorption in the most sensitive region varying as 1/R5/2 . Specific parameters for single protein or virus particle detection are predicted. IS - 4 JF - Opt. Lett. EP - 274 TI - Shift of whispering-gallery modes in microspheres by protein adsorption PB - OSA VL - 28 SP - 272 KW - biosensor KW - cavity_resonator KW - experiment KW - protein KW - resonant_sensor KW - spherical_resonator AU - Arnold, S AU - Khoshsima, M AU - Teraoka, I AU - Holler, S AU - Vollmer, F PY - 2003/02/15/ UR - http://dx.doi.org/10.1364/OL.28.000272 ER -