Integrated Refractive Index Optical Ring Resonator Detector for Capillary Electrophoresis Export

@article{citeulike:4192030, abstract = {PMID: 17263318 We developed a novel miniaturized and multiplexed, on-capillary, refractive index (RI) detector using liquid core optical ring resonators (LCORRs) for future development of capillary electrophoresis (CE) devices. The LCORR employs a glass capillary with a diameter of 100 mum and a wall thickness of a few micrometers. The circular cross section of the capillary forms a ring resonator along which the light circulates in the form of the whispering gallery modes (WGMs). The WGM has an evanescent field extending into the capillary core and responds to the RI change due to the analyte conducted in the capillary, thus permitting label-free measurement. The resonating nature of the WGM enables repetitive lightanalyte interaction, significantly enhancing the LCORR sensitivity. This LCORR architecture achieves dual use of the capillary as a sensor head and a CE fluidic channel, allowing for integrated, multiplexed, and noninvasive on-capillary detection at any location along the capillary. In this work, we used electro-osmotic flow and glycerol as a model system to demonstrate the fluid transport capability of the LCORRs. In addition, we performed flow speed measurement on the LCORR to demonstrate its flow analysis capability. Finally, using the LCORR's label-free sensing mechanism, we accurately deduced the analyte concentration in real time at a given point on the capillary. A sensitivity of 20 nm/RIU (refractive index units) was observed, leading to an RI detection limit of 10-6 RIU. The LCORR marries photonic technology with microfluidics and enables rapid on-capillary sample analysis and flow profile monitoring. The investigation in this regard will open a door to novel high-throughput CE devices and lab-on-a-chip sensors in the future.}, author = {Zhu, Hongying and White, Ian M. and Suter, Jonathan D. and Zourob, Mohammed and Fan, Xudong}, citeulike-article-id = {4192030}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/ac061279q}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/ac061279q}, day = {1}, doi = {10.1021/ac061279q}, journal = {Analytical Chemistry}, keywords = {capillary, experiment, hardcopy, liquid\_core, multiplex, refractive\_index, ring\_resonator, sensor, thermo\_optic}, month = {February}, number = {3}, pages = {930--937}, posted-at = {2009-09-10 16:41:10}, priority = {2}, title = {Integrated Refractive Index Optical Ring Resonator Detector for Capillary Electrophoresis}, url = {http://dx.doi.org/10.1021/ac061279q}, volume = {79}, year = {2007} }

TY - JOUR ID - citeulike:4192030 L3 - citeulike-article-id:4192030 N2 - PMID: 17263318 We developed a novel miniaturized and multiplexed, on-capillary, refractive index (RI) detector using liquid core optical ring resonators (LCORRs) for future development of capillary electrophoresis (CE) devices. The LCORR employs a glass capillary with a diameter of 100 mum and a wall thickness of a few micrometers. The circular cross section of the capillary forms a ring resonator along which the light circulates in the form of the whispering gallery modes (WGMs). The WGM has an evanescent field extending into the capillary core and responds to the RI change due to the analyte conducted in the capillary, thus permitting label-free measurement. The resonating nature of the WGM enables repetitive lightanalyte interaction, significantly enhancing the LCORR sensitivity. This LCORR architecture achieves dual use of the capillary as a sensor head and a CE fluidic channel, allowing for integrated, multiplexed, and noninvasive on-capillary detection at any location along the capillary. In this work, we used electro-osmotic flow and glycerol as a model system to demonstrate the fluid transport capability of the LCORRs. In addition, we performed flow speed measurement on the LCORR to demonstrate its flow analysis capability. Finally, using the LCORR's label-free sensing mechanism, we accurately deduced the analyte concentration in real time at a given point on the capillary. A sensitivity of 20 nm/RIU (refractive index units) was observed, leading to an RI detection limit of 10-6 RIU. The LCORR marries photonic technology with microfluidics and enables rapid on-capillary sample analysis and flow profile monitoring. The investigation in this regard will open a door to novel high-throughput CE devices and lab-on-a-chip sensors in the future. IS - 3 JF - Analytical Chemistry EP - 937 TI - Integrated Refractive Index Optical Ring Resonator Detector for Capillary Electrophoresis VL - 79 SP - 930 KW - capillary KW - experiment KW - hardcopy KW - liquid_core KW - multiplex KW - refractive_index KW - ring_resonator KW - sensor KW - thermo_optic AU - Zhu, Hongying AU - White, Ian AU - Suter, Jonathan AU - Zourob, Mohammed AU - Fan, Xudong PY - 2007/02/01/ UR - http://dx.doi.org/10.1021/ac061279q ER -