Label-free biosensor by protein grating coupler on planar optical waveguides Export

@article{citeulike:5935956, abstract = {We report a diffraction-based, label-free biosensor on the surface of a planar optical waveguide. By selectively immobilizing proteins on an optical waveguide, the proteins can form the ridge/valley of a latent image optical grating. Binding events with patterned surface proteins dynamically increase grating height and cause an increase in light coupling out of the waveguide. We demonstrate the efficacy of this strategy for protein detection and present the design and fabrication of a device.}, author = {Lai, Zhian and Wang, Yuli and Allbritton, Nancy and Li, G. P. and Bachman, Mark}, citeulike-article-id = {5935956}, citeulike-linkout-0 = {http://dx.doi.org/10.1364/OL.33.001735}, citeulike-linkout-1 = {http://www.opticsinfobase.org/abstract.cfm?id=170145}, day = {1}, doi = {10.1364/OL.33.001735}, journal = {Opt. Lett.}, keywords = {biosensor, bsa, electron\_beam, gops, grating, lithography, pmma, protein, silicon\_nitride, waveguide}, month = {August}, number = {15}, pages = {1735--1737}, posted-at = {2009-10-13 13:03:34}, priority = {2}, publisher = {OSA}, title = {Label-free biosensor by protein grating coupler on planar optical waveguides}, url = {http://dx.doi.org/10.1364/OL.33.001735}, volume = {33}, year = {2008} }

TY - JOUR ID - citeulike:5935956 L3 - citeulike-article-id:5935956 N2 - We report a diffraction-based, label-free biosensor on the surface of a planar optical waveguide. By selectively immobilizing proteins on an optical waveguide, the proteins can form the ridge/valley of a latent image optical grating. Binding events with patterned surface proteins dynamically increase grating height and cause an increase in light coupling out of the waveguide. We demonstrate the efficacy of this strategy for protein detection and present the design and fabrication of a device. IS - 15 JF - Opt. Lett. EP - 1737 TI - Label-free biosensor by protein grating coupler on planar optical waveguides PB - OSA VL - 33 SP - 1735 KW - biosensor KW - bsa KW - electron_beam KW - gops KW - grating KW - lithography KW - pmma KW - protein KW - silicon_nitride KW - waveguide AU - Lai, Zhian AU - Wang, Yuli AU - Allbritton, Nancy AU - Li, GP AU - Bachman, Mark PY - 2008/08/01/ UR - http://dx.doi.org/10.1364/OL.33.001735 ER -