A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips Export

@article{citeulike:6107441, abstract = {We present the design, fabrication, and characterisation of an array of optical slot-waveguide ring resonator sensors, integrated with microfluidic sample handling in a compact cartridge, for multiplexed real-time label-free biosensing. Multiplexing not only enables high throughput, but also provides reference channels for drift compensation and control experiments. Our use of alignment tolerant surface gratings to couple light into the optical chip enables quick replacement of cartridges in the read-out instrument. Furthermore, our novel use of a dual surface-energy adhesive film to bond a hard plastic shell directly to the PDMS microfluidic network allows for fast and leak-tight assembly of compact cartridges with tightly spaced fluidic interconnects. The high sensitivity of the slot-waveguide resonators, combined with on-chip referencing and physical modelling, yields a volume refractive index detection limit of 5 [times] 10-6 refractive index units (RIUs) and a surface mass density detection limit of 0.9 pg mm-2, to our knowledge the best reported values for integrated planar ring resonators.}, author = {Carlborg, C. F. and Gylfason, K. B. and Kazmierczak, A. and Dortou, F. and Polo, M. J. Banuls and Catala, A. Maquieira and Kresbach, G. M. and Sohlstrom, H. and Moh, T. and Vivien, L. and Popplewell, J. and Ronan, G. and Barrios, C. A. and Stemme, G. and Wijngaart}, citeulike-article-id = {6107441}, citeulike-linkout-0 = {http://dx.doi.org/10.1039/b914183a}, citeulike-linkout-1 = {http://www.rsc.org/Publishing/Journals/article.asp?doi=b914183a}, doi = {10.1039/b914183a}, journal = {Lab Chip}, keywords = {antibody, biosensor, bsa, experiment, kth\_papers, mst\_papers, own\_paper, refractometry, sabio, sensor, silicon\_nitride, silicon\_oxide, slot\_waveguide, waveguide}, posted-at = {2009-11-13 05:18:51}, priority = {0}, publisher = {The Royal Society of Chemistry}, title = {A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips}, url = {http://dx.doi.org/10.1039/b914183a}, year = {2010} }

TY - JOUR ID - citeulike:6107441 L3 - citeulike-article-id:6107441 N2 - We present the design, fabrication, and characterisation of an array of optical slot-waveguide ring resonator sensors, integrated with microfluidic sample handling in a compact cartridge, for multiplexed real-time label-free biosensing. Multiplexing not only enables high throughput, but also provides reference channels for drift compensation and control experiments. Our use of alignment tolerant surface gratings to couple light into the optical chip enables quick replacement of cartridges in the read-out instrument. Furthermore, our novel use of a dual surface-energy adhesive film to bond a hard plastic shell directly to the PDMS microfluidic network allows for fast and leak-tight assembly of compact cartridges with tightly spaced fluidic interconnects. The high sensitivity of the slot-waveguide resonators, combined with on-chip referencing and physical modelling, yields a volume refractive index detection limit of 5 [times] 10-6 refractive index units (RIUs) and a surface mass density detection limit of 0.9 pg mm-2, to our knowledge the best reported values for integrated planar ring resonators. JF - Lab Chip TI - A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips PB - The Royal Society of Chemistry KW - antibody KW - biosensor KW - bsa KW - experiment KW - kth_papers KW - mst_papers KW - own_paper KW - refractometry KW - sabio KW - sensor KW - silicon_nitride KW - silicon_oxide KW - slot_waveguide KW - waveguide AU - Carlborg, CF AU - Gylfason, KB AU - Kazmierczak, A AU - Dortou, F AU - Polo, Banuls AU - Catala, Maquieira AU - Kresbach, GM AU - Sohlstrom, H AU - Moh, T AU - Vivien, L AU - Popplewell, J AU - Ronan, G AU - Barrios, CA AU - Stemme, G AU - Wijngaart PY - 2010/// UR - http://dx.doi.org/10.1039/b914183a ER -