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MicroRNAs in the Human Heart

by: Thomas Thum, Paolo Galuppo, Christian Wolf, Jan Fiedler, Susanne Kneitz, Linda W. van Laake, Pieter A. Doevendans, Christine L. Mummery, Jürgen Borlak, Axel Haverich, Carina Gross, Stefan Engelhardt, Georg Ertl, Johann Bauersachs
Circulation, Vol. 116, No. 3. (17 July 2007), pp. 258-267, doi:10.1161/circulationaha.107.687947  Key: citeulike:12027757

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Abstract

Background— Chronic heart failure is characterized by left ventricular remodeling and reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here we provide evidence that cardiac microRNAs, recently discovered key regulators of gene expression, contribute to the transcriptional changes observed in heart failure.


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