De Novo Formation of a Subnuclear Body Export

@article{citeulike:3720725, abstract = {The mammalian cell nucleus contains structurally stable functional compartments. We show here that one of them, the Cajal body (CB), can be formed de novo. Immobilization on chromatin of both CB structural components, such as coilin, and functional components of the CB, such as the SMN complex, spliceosomal small nuclear ribonucleoproteins (RNPs), small nucleolar RNPs, and small Cajal body-specific RNPs, is sufficient for the formation of a morphologically normal and apparently functional CB. Biogenesis of the CB does not follow a hierarchical assembly pathway and exhibits hallmarks of a self-organizing structure. 10.1126/science.1165216}, author = {Kaiser, Trish E. and Intine, Robert V. and Dundr, Miroslav}, citeulike-article-id = {3720725}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1165216}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/322/5908/1713}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18948503}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18948503}, day = {12}, doi = {10.1126/science.1165216}, journal = {Science}, keywords = {cajal\_body}, month = {December}, number = {5908}, pages = {1713--1717}, posted-at = {2008-11-28 11:26:52}, priority = {2}, title = {De Novo Formation of a Subnuclear Body}, url = {http://dx.doi.org/10.1126/science.1165216}, volume = {322}, year = {2008} }

TY - JOUR ID - citeulike:3720725 L3 - citeulike-article-id:3720725 N2 - The mammalian cell nucleus contains structurally stable functional compartments. We show here that one of them, the Cajal body (CB), can be formed de novo. Immobilization on chromatin of both CB structural components, such as coilin, and functional components of the CB, such as the SMN complex, spliceosomal small nuclear ribonucleoproteins (RNPs), small nucleolar RNPs, and small Cajal body-specific RNPs, is sufficient for the formation of a morphologically normal and apparently functional CB. Biogenesis of the CB does not follow a hierarchical assembly pathway and exhibits hallmarks of a self-organizing structure. 10.1126/science.1165216 IS - 5908 JF - Science EP - 1717 TI - De Novo Formation of a Subnuclear Body VL - 322 SP - 1713 KW - cajal_body AU - Kaiser, Trish AU - Intine, Robert AU - Dundr, Miroslav PY - 2008/12/12/ UR - http://dx.doi.org/10.1126/science.1165216 ER -