[S1] Cell packing influences planar cell polarity signaling Export

@article{citeulike:3744042, abstract = {10.1073/pnas.0808868105 Some epithelial cells display asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (PCP). A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes. The feedback loop can propagate polarity across clones of cells that lack the global directional signal, although this polarity propagation is error prone. Here, we show that, in the wing, a combination of cell geometry and nonautonomous signaling at clone boundaries determines the correct or incorrect polarity propagation in clones that lack Fat mediated global directional information. Pattern elements, such as veins, and sporadic occurrences of irregular geometry are obstacles to polarity propagation. Hence, in the wild type, broad distribution of the global directional cue combines with a local feedback mechanism to overcome irregularities in cell packing geometry during PCP signaling.}, author = {Ma, Dali and Amonlirdviman, Keith and Raffard, Robin L. and Abate, Alessandro and Tomlin, Claire J. and Axelrod, Jeffrey D.}, citeulike-article-id = {3744042}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0808868105}, day = {2}, doi = {10.1073/pnas.0808868105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {cell\_shape}, month = {December}, number = {48}, pages = {18800--18805}, posted-at = {2008-12-03 21:55:49}, priority = {2}, title = {[S1] Cell packing influences planar cell polarity signaling}, url = {http://dx.doi.org/10.1073/pnas.0808868105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3744042 L3 - citeulike-article-id:3744042 N2 - 10.1073/pnas.0808868105 Some epithelial cells display asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (PCP). A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes. The feedback loop can propagate polarity across clones of cells that lack the global directional signal, although this polarity propagation is error prone. Here, we show that, in the wing, a combination of cell geometry and nonautonomous signaling at clone boundaries determines the correct or incorrect polarity propagation in clones that lack Fat mediated global directional information. Pattern elements, such as veins, and sporadic occurrences of irregular geometry are obstacles to polarity propagation. Hence, in the wild type, broad distribution of the global directional cue combines with a local feedback mechanism to overcome irregularities in cell packing geometry during PCP signaling. IS - 48 JF - Proceedings of the National Academy of Sciences EP - 18805 TI - [S1] Cell packing influences planar cell polarity signaling VL - 105 SP - 18800 KW - cell_shape AU - Ma, Dali AU - Amonlirdviman, Keith AU - Raffard, Robin AU - Abate, Alessandro AU - Tomlin, Claire AU - Axelrod, Jeffrey PY - 2008/12/02/ UR - http://dx.doi.org/10.1073/pnas.0808868105 ER -