5-HT2 receptors in Drosophila are expressed in the brain and modulate aspects of circadian behaviors. Export

@article{citeulike:3392467, abstract = {Dysregulation of 5-HT(2) receptor function has been strongly implicated in many neuropsychiatric disorders, including schizophrenia. At present, the molecular mechanisms linking 5-HT(2) receptor activation to behaviors is not well understood. In efforts to elucidate these processes, the fruit fly, Drosophila melanogaster, is proposed to serve as a powerful genetically tractable model organism to study 5-HT(2) receptor function. Data are presented here on the expression of the fly ortholog of the mammalian 5-HT(2) receptor, 5-HT(2)Dro, in the larval and adult brain of the fly, and on the involvement of these circuits in certain circadian behaviors. In the adult brain, 5-HT(2)Dro is expressed in the protocerebrum and ellipsoid body, areas believed to participate in higher order behaviors including learning, locomotion, and sensory perception. In the third instar larva, 5-HT(2)Dro receptor expression is detected in a specific pattern that markedly changes from early to late third instar. To probe the function of this receptor we have examined the effects of the 5-HT(2) receptor-specific agonist DOI in wild type and 5-HT(2)Dro hypomorphic flies on circadian behaviors. DOI was found to increase early day activity, eliminate anticipatory behavior, and reduce viability. The effects of DOI were significantly diminished in a 5-HT(2)Dro hypomorphic strain. Identifying the 5-HT(2)Dro receptor circuitry and behaviors they mediate are significant steps towards developing this model system to study conserved molecular mechanisms underlying behaviors mediated by 5-HT(2) receptors in mammalian systems.}, author = {Nichols, C. D.}, citeulike-article-id = {3392467}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/dneu.20370}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17443822}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17443822}, doi = {10.1002/dneu.20370}, issn = {1932-8451}, journal = {Developmental neurobiology}, keywords = {all-articles}, month = {May}, number = {6}, pages = {752--763}, posted-at = {2008-10-10 06:59:11}, priority = {4}, title = {5-HT2 receptors in Drosophila are expressed in the brain and modulate aspects of circadian behaviors.}, url = {http://dx.doi.org/10.1002/dneu.20370}, volume = {67}, year = {2007} }

TY - JOUR ID - citeulike:3392467 L3 - citeulike-article-id:3392467 N2 - Dysregulation of 5-HT(2) receptor function has been strongly implicated in many neuropsychiatric disorders, including schizophrenia. At present, the molecular mechanisms linking 5-HT(2) receptor activation to behaviors is not well understood. In efforts to elucidate these processes, the fruit fly, Drosophila melanogaster, is proposed to serve as a powerful genetically tractable model organism to study 5-HT(2) receptor function. Data are presented here on the expression of the fly ortholog of the mammalian 5-HT(2) receptor, 5-HT(2)Dro, in the larval and adult brain of the fly, and on the involvement of these circuits in certain circadian behaviors. In the adult brain, 5-HT(2)Dro is expressed in the protocerebrum and ellipsoid body, areas believed to participate in higher order behaviors including learning, locomotion, and sensory perception. In the third instar larva, 5-HT(2)Dro receptor expression is detected in a specific pattern that markedly changes from early to late third instar. To probe the function of this receptor we have examined the effects of the 5-HT(2) receptor-specific agonist DOI in wild type and 5-HT(2)Dro hypomorphic flies on circadian behaviors. DOI was found to increase early day activity, eliminate anticipatory behavior, and reduce viability. The effects of DOI were significantly diminished in a 5-HT(2)Dro hypomorphic strain. Identifying the 5-HT(2)Dro receptor circuitry and behaviors they mediate are significant steps towards developing this model system to study conserved molecular mechanisms underlying behaviors mediated by 5-HT(2) receptors in mammalian systems. IS - 6 JF - Developmental neurobiology SN - 1932-8451 EP - 763 TI - 5-HT2 receptors in Drosophila are expressed in the brain and modulate aspects of circadian behaviors. VL - 67 SP - 752 KW - all-articles AU - Nichols, CD PY - 2007/05// UR - http://dx.doi.org/10.1002/dneu.20370 ER -