[Multiplicity of anxiety and serotonin nervous system] Export

@article{citeulike:3392476, abstract = {It has been recently suggested that the central serotonin (5-HT) nervous system may be involved in the modulation of anxiety. Especially, the possible importance of 5-HT1A receptors in anxiety was raised by evidence that the anxiolytic properties of 5-HT1A-receptor agonists have now been confirmed in clinical studies. On the other hand, in preclinical studies using various animal models of anxiety, these novel agents tend to have weak and/or variable effects in some paradigms used to detect the anxiolytic activities of benzodiazepines. These differential patterns of drug effects within various models promote the concept of "multiplicity of anxiety". Recently, a new experimental model called the T-maze was developed in attempts to analyze a different type of anxiety; i.e., conditioned fear and unconditioned fear response. The results of a series of behavioral studies using the T-maze test suggest that distinct 5-HT pathways may modulate the different classes of anxiety. In our recent studies using the hole-board test, apparent differential behavioral effects between benzodiazepine anxiolytics and 5-HT1A agonists on emotionality of stressed mice were also observed. These results suggest that benzodiazepine or 5-HT1A receptors may play a different role in modulating emotionality. These studies may provide new information to investigate the pathophysiological characteristics of various types of anxiety disorders and to develop novel therapeutic agents.}, author = {Tsuji, M. and Takeda, H. and Matsumiya, T.}, citeulike-article-id = {3392476}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10876813}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10876813}, issn = {0015-5691}, journal = {Nippon yakurigaku zasshi. Folia pharmacologica Japonica}, keywords = {all-articles}, month = {January}, number = {1}, pages = {29--38}, posted-at = {2008-10-10 07:06:10}, priority = {2}, title = {[Multiplicity of anxiety and serotonin nervous system]}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10876813}, volume = {115}, year = {2000} }

TY - JOUR ID - citeulike:3392476 L3 - citeulike-article-id:3392476 N2 - It has been recently suggested that the central serotonin (5-HT) nervous system may be involved in the modulation of anxiety. Especially, the possible importance of 5-HT1A receptors in anxiety was raised by evidence that the anxiolytic properties of 5-HT1A-receptor agonists have now been confirmed in clinical studies. On the other hand, in preclinical studies using various animal models of anxiety, these novel agents tend to have weak and/or variable effects in some paradigms used to detect the anxiolytic activities of benzodiazepines. These differential patterns of drug effects within various models promote the concept of "multiplicity of anxiety". Recently, a new experimental model called the T-maze was developed in attempts to analyze a different type of anxiety; i.e., conditioned fear and unconditioned fear response. The results of a series of behavioral studies using the T-maze test suggest that distinct 5-HT pathways may modulate the different classes of anxiety. In our recent studies using the hole-board test, apparent differential behavioral effects between benzodiazepine anxiolytics and 5-HT1A agonists on emotionality of stressed mice were also observed. These results suggest that benzodiazepine or 5-HT1A receptors may play a different role in modulating emotionality. These studies may provide new information to investigate the pathophysiological characteristics of various types of anxiety disorders and to develop novel therapeutic agents. IS - 1 JF - Nippon yakurigaku zasshi. Folia pharmacologica Japonica SN - 0015-5691 EP - 38 TI - [Multiplicity of anxiety and serotonin nervous system] VL - 115 SP - 29 KW - all-articles AU - Tsuji, M AU - Takeda, H AU - Matsumiya, T PY - 2000/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/10876813 ER -