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A meta-analysis of the effects of cognitive therapy in depressed patients Export

Journal of Affective Disorders, Vol. 49, No. 1. (1 May 1998), pp. 59-72.

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Background . Cognitive therapy (CT) has been studied in 78 controlled clinical trials from 1977 to 1996. Method . The meta-analysis used Hedges and Olkin d+ and included 48 high-quality controlled trials. The 2765 patients presented non-psychotic and non-bipolar major depression, or dysthymia of mild to moderate severity. Results . At post-test CT appeared significantly better than waiting-list, antidepressants ( P <0.0001) and a group of miscellaneous therapies ( P <0.01). But, CT was equal to behaviour therapy. As between-trial homogeneity was not met, the comparisons of CT with waiting-list or placebo, and other therapies should be taken cautiously. In contrast, between-trial homogeneity was high for the comparisons of CT with behaviour therapy and antidepressants. A review of eight follow-up studies comparing CT with antidepressants suggested that CT may prevent relapses in the long-term, while relapse rate is high with antidepressants in naturalistic studies. Conclusion . CT is effective in patients with mild or moderate depression.


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