Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging. Export

@article{citeulike:131503, abstract = {Criteria for defining biomarkers have been suggested. Accumulation of dolichol in tissues of older animals meets the following criteria: (a) levels of dolichol exhibit a quantitative correlation with age in all tissues and are not altered by several age-dependent diseases in the same direction as that of aging; (b) accumulation is not secondary to metabolic changes of aging and is altered appropriately by factors that modulate the aging rate like caloric restriction and physical exercise; (c) biomarker is applicable to different tissues across mammalian species, including humans, and to trisomy 21 and its hypothalamic digoxin-mediated model. Reliable changes in tissue dolichol levels are seen in relatively short intervals of time compared to over a life span, and levels can be tested on a small amount of tissue without causing death of the animal. In this article, we show applications to the study of host-graft interaction and detection of gender-related differences in biological age, and we discuss mechanism(s) of accumulation.}, address = {Professor, Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, Via Roma 55-Scuola Medica, 56126 Pisa, Italy. ebergami@med.unipi.it.}, author = {Parentini, I. and Cavallini, G. and Donati, A. and Gori, Z. and Bergamini, E.}, citeulike-article-id = {131503}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15741281}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15741281}, issn = {1079-5006}, journal = {J Gerontol A Biol Sci Med Sci}, keywords = {anti-aging}, month = {January}, number = {1}, pages = {39--43}, posted-at = {2005-03-17 20:23:22}, priority = {2}, title = {Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15741281}, volume = {60}, year = {2005} }

TY - JOUR ID - citeulike:131503 L3 - citeulike-article-id:131503 N2 - Criteria for defining biomarkers have been suggested. Accumulation of dolichol in tissues of older animals meets the following criteria: (a) levels of dolichol exhibit a quantitative correlation with age in all tissues and are not altered by several age-dependent diseases in the same direction as that of aging; (b) accumulation is not secondary to metabolic changes of aging and is altered appropriately by factors that modulate the aging rate like caloric restriction and physical exercise; (c) biomarker is applicable to different tissues across mammalian species, including humans, and to trisomy 21 and its hypothalamic digoxin-mediated model. Reliable changes in tissue dolichol levels are seen in relatively short intervals of time compared to over a life span, and levels can be tested on a small amount of tissue without causing death of the animal. In this article, we show applications to the study of host-graft interaction and detection of gender-related differences in biological age, and we discuss mechanism(s) of accumulation. IS - 1 JF - J Gerontol A Biol Sci Med Sci SN - 1079-5006 AD - Professor, Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, Via Roma 55-Scuola Medica, 56126 Pisa, Italy. ebergami@med.unipi.it. EP - 43 TI - Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging. VL - 60 SP - 39 KW - anti-aging AU - Parentini, I AU - Cavallini, G AU - Donati, A AU - Gori, Z AU - Bergamini, E PY - 2005/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/15741281 ER -