Divergent effects of caloric restriction on gene expression in normal and long-lived mice. Export

@article{citeulike:72837, abstract = {Long-lived Ames dwarf mice share many phenotypic characteristics with animals subjected to caloric restriction (CR) but they are not CR mimetics. CR prolongs longevity in both normal and Ames dwarf mice. Using real-time polymerase chain reaction and western blot, we have examined the expression of genes related to insulin signaling in the liver of normal and dwarf mice subjected to 30\% CR. The results revealed divergent responses of dwarf and normal animals to CR raising an interesting possibility that CR may affect longevity of normal and dwarf mice by different mechanisms. Moreover, effects of dwarfism on the expression of the examined genes differed from the effects of CR, thus adding to the evidence that these long-lived mutants are not CR mimetics.}, address = {Department of Internal Medicine, Southern Illinois University, School of Medicine, Springfield 62794-9628, USA. mmasternak@siumed.edu}, author = {Masternak, M. M. and Al-Regaiey, K. and Bonkowski, M. S. and Panici, J. and Sun, L. and Wang, J. and Przybylski, G. K. and Bartke, A.}, citeulike-article-id = {72837}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15345726}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15345726}, issn = {1079-5006}, journal = {J Gerontol A Biol Sci Med Sci}, keywords = {anti-aging, cr}, month = {August}, number = {8}, pages = {784--788}, posted-at = {2005-01-06 20:22:40}, title = {Divergent effects of caloric restriction on gene expression in normal and long-lived mice.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15345726}, volume = {59}, year = {2004} }

TY - JOUR ID - citeulike:72837 L3 - citeulike-article-id:72837 N2 - Long-lived Ames dwarf mice share many phenotypic characteristics with animals subjected to caloric restriction (CR) but they are not CR mimetics. CR prolongs longevity in both normal and Ames dwarf mice. Using real-time polymerase chain reaction and western blot, we have examined the expression of genes related to insulin signaling in the liver of normal and dwarf mice subjected to 30% CR. The results revealed divergent responses of dwarf and normal animals to CR raising an interesting possibility that CR may affect longevity of normal and dwarf mice by different mechanisms. Moreover, effects of dwarfism on the expression of the examined genes differed from the effects of CR, thus adding to the evidence that these long-lived mutants are not CR mimetics. IS - 8 JF - J Gerontol A Biol Sci Med Sci SN - 1079-5006 AD - Department of Internal Medicine, Southern Illinois University, School of Medicine, Springfield 62794-9628, USA. mmasternak@siumed.edu EP - 788 TI - Divergent effects of caloric restriction on gene expression in normal and long-lived mice. VL - 59 SP - 784 KW - anti-aging KW - cr AU - Masternak, MM AU - Al-Regaiey, K AU - Bonkowski, MS AU - Panici, J AU - Sun, L AU - Wang, J AU - Przybylski, GK AU - Bartke, A PY - 2004/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/15345726 ER -