High-resolution diffusivity imaging at 3.0 T for the detection of degenerative changes: a trypsin-based arthritis model. Export

@article{berg2003a, abstract = {RATIONALE AND OBJECTIVES: To establish whether it is possible to quantitatively characterize the degenerative changes in cartilage that typify arthritis on a sub-150-microm resolution scale using a 3.0 T whole body MR-scanner with a reasonable measurement time. MATERIALS AND METHODS: This problem is addressed through diffusion-microimaging investigations on an arthritis model based on the enzymatic destruction of the proteoglycans in cartilage specimen. A 35-mm birdcage resonator made high spatial resolution possible, and diffusion-micro-imaging was achieved with the use of a strong gradient system. RESULTS: Diffusion-weighted and quantitative parameter maps were acquired with 117 x 234 microm2 pixel resolution in less than 9 minutes. Diffusivity profiles and parameter images exhibit an increase in diffusivity in degenerated tissue. CONCLUSION: In a trypsin-based arthritis model, the spatial localization and quantification of damaged areas have been shown to be possible on a whole body 3.0 T MR system. Measurement times achieved for these high spatial resolution studies make in vivo investigations feasible.}, author = {Berg, Andreas and Singer, Thomas and Moser, Ewald}, citeulike-article-id = {5853038}, citeulike-linkout-0 = {http://dx.doi.org/10.1097/01.rli.0000078762.72335.57}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12821861}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12821861}, doi = {10.1097/01.rli.0000078762.72335.57}, issn = {0020-9996}, journal = {Investigative radiology}, keywords = {arthritis, high-resolution, microscopy}, month = {July}, number = {7}, pages = {460--466}, posted-at = {2009-09-29 18:32:58}, priority = {2}, title = {High-resolution diffusivity imaging at 3.0 T for the detection of degenerative changes: a trypsin-based arthritis model.}, url = {http://dx.doi.org/10.1097/01.rli.0000078762.72335.57}, volume = {38}, year = {2003} }

TY - JOUR ID - berg2003a L3 - citeulike-article-id:5853038 N2 - RATIONALE AND OBJECTIVES: To establish whether it is possible to quantitatively characterize the degenerative changes in cartilage that typify arthritis on a sub-150-microm resolution scale using a 3.0 T whole body MR-scanner with a reasonable measurement time. MATERIALS AND METHODS: This problem is addressed through diffusion-microimaging investigations on an arthritis model based on the enzymatic destruction of the proteoglycans in cartilage specimen. A 35-mm birdcage resonator made high spatial resolution possible, and diffusion-micro-imaging was achieved with the use of a strong gradient system. RESULTS: Diffusion-weighted and quantitative parameter maps were acquired with 117 x 234 microm2 pixel resolution in less than 9 minutes. Diffusivity profiles and parameter images exhibit an increase in diffusivity in degenerated tissue. CONCLUSION: In a trypsin-based arthritis model, the spatial localization and quantification of damaged areas have been shown to be possible on a whole body 3.0 T MR system. Measurement times achieved for these high spatial resolution studies make in vivo investigations feasible. IS - 7 JF - Investigative radiology SN - 0020-9996 EP - 466 TI - High-resolution diffusivity imaging at 3.0 T for the detection of degenerative changes: a trypsin-based arthritis model. VL - 38 SP - 460 KW - arthritis KW - high-resolution KW - microscopy AU - Berg, Andreas AU - Singer, Thomas AU - Moser, Ewald PY - 2003/07// UR - http://dx.doi.org/10.1097/01.rli.0000078762.72335.57 ER -