Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya. Export

@article{citeulike:1735711, abstract = {BACKGROUND: It has been hypothesized that the African alleles Sl2 and McCb of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. METHODS: To test this hypothesis, children in western Kenya with severe malaria-associated anaemia or cerebral malaria were matched to symptomatic uncomplicated malaria controls by age and gender. Swain-Langley and McCoy blood group alleles were determined by restriction fragment length polymorphism and conditional logistic regression was carried out. RESULTS: No significant association was found between the African alleles and severe malaria-associated anaemia. However, children with Sl2/2 genotype were less likely to have cerebral malaria (OR = 0.17, 95\% CI 0.04 to 0.72, P = 0.02) than children with Sl1/1. In particular, individuals with Sl2/2 McC(a/b) genotype were less likely to have cerebral malaria (OR = 0.18, 95\% CI 0.04 to 0.77, P = 0.02) than individuals with Sl1/1 McC(a/a). CONCLUSION: These results support the hypothesis that the Sl2 allele and, possibly, the McCb allele evolved in the context of malaria transmission and that in certain combinations probably confer a survival advantage on these populations.}, address = {The US Army Medical Research Unit, The Kenya Medical Research Institute, Nairobi, Kenya. vthathy@wrp-ksm.org}, author = {Thathy, V. and Moulds, J. M. and Guyah, B. and Otieno, W. and Stoute, J. A.}, citeulike-article-id = {1735711}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1475-2875-4-54}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16277654}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16277654}, doi = {10.1186/1475-2875-4-54}, issn = {1475-2875}, journal = {Malar J}, keywords = {cr1, malaria}, posted-at = {2007-10-07 10:25:47}, priority = {0}, title = {Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya.}, url = {http://dx.doi.org/10.1186/1475-2875-4-54}, volume = {4}, year = {2005} }

TY - JOUR ID - citeulike:1735711 L3 - citeulike-article-id:1735711 N2 - BACKGROUND: It has been hypothesized that the African alleles Sl2 and McCb of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. METHODS: To test this hypothesis, children in western Kenya with severe malaria-associated anaemia or cerebral malaria were matched to symptomatic uncomplicated malaria controls by age and gender. Swain-Langley and McCoy blood group alleles were determined by restriction fragment length polymorphism and conditional logistic regression was carried out. RESULTS: No significant association was found between the African alleles and severe malaria-associated anaemia. However, children with Sl2/2 genotype were less likely to have cerebral malaria (OR = 0.17, 95% CI 0.04 to 0.72, P = 0.02) than children with Sl1/1. In particular, individuals with Sl2/2 McC(a/b) genotype were less likely to have cerebral malaria (OR = 0.18, 95% CI 0.04 to 0.77, P = 0.02) than individuals with Sl1/1 McC(a/a). CONCLUSION: These results support the hypothesis that the Sl2 allele and, possibly, the McCb allele evolved in the context of malaria transmission and that in certain combinations probably confer a survival advantage on these populations. JF - Malar J SN - 1475-2875 AD - The US Army Medical Research Unit, The Kenya Medical Research Institute, Nairobi, Kenya. vthathy@wrp-ksm.org TI - Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya. VL - 4 KW - cr1 KW - malaria AU - Thathy, V AU - Moulds, JM AU - Guyah, B AU - Otieno, W AU - Stoute, JA PY - 2005/// UR - http://dx.doi.org/10.1186/1475-2875-4-54 ER -