Basic local alignment search tool. Export

@article{citeulike:100088, abstract = {A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score. Recent mathematical results on the stochastic properties of MSP scores allow an analysis of the performance of this method as well as the statistical significance of alignments it generates. The basic algorithm is simple and robust; it can be implemented in a number of ways and applied in a variety of contexts including straightforward DNA and protein sequence database searches, motif searches, gene identification searches, and in the analysis of multiple regions of similarity in long DNA sequences. In addition to its flexibility and tractability to mathematical analysis, BLAST is an order of magnitude faster than existing sequence comparison tools of comparable sensitivity.}, address = {National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894.}, author = {Altschul, S. F. and Gish, W. and Miller, W. and Myers, E. W. and Lipman, D. J.}, citeulike-article-id = {100088}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/jmbi.1990.9999}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0022-2836(80)79999-0}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/2231712}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=2231712}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6WK7-45PV640-2J/2/57a0a7cd25f342367d4f1daf09ac89e8}, citeulike-linkout-5 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00024706}, day = {5}, doi = {10.1006/jmbi.1990.9999}, issn = {0022-2836}, journal = {Journal of molecular biology}, keywords = {golgo}, month = {October}, number = {3}, pages = {403--410}, posted-at = {2009-01-30 14:05:13}, priority = {2}, title = {Basic local alignment search tool.}, url = {http://dx.doi.org/10.1006/jmbi.1990.9999}, volume = {215}, year = {1990} }

TY - JOUR ID - citeulike:100088 L3 - citeulike-article-id:100088 N2 - A new approach to rapid sequence comparison, basic local alignment search tool (BLAST), directly approximates alignments that optimize a measure of local similarity, the maximal segment pair (MSP) score. Recent mathematical results on the stochastic properties of MSP scores allow an analysis of the performance of this method as well as the statistical significance of alignments it generates. The basic algorithm is simple and robust; it can be implemented in a number of ways and applied in a variety of contexts including straightforward DNA and protein sequence database searches, motif searches, gene identification searches, and in the analysis of multiple regions of similarity in long DNA sequences. In addition to its flexibility and tractability to mathematical analysis, BLAST is an order of magnitude faster than existing sequence comparison tools of comparable sensitivity. IS - 3 JF - Journal of molecular biology SN - 0022-2836 AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894. EP - 410 TI - Basic local alignment search tool. VL - 215 SP - 403 KW - golgo AU - Altschul, SF AU - Gish, W AU - Miller, W AU - Myers, EW AU - Lipman, DJ PY - 1990/10/05/ UR - http://dx.doi.org/10.1006/jmbi.1990.9999 ER -