A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast Export

@article{citeulike:1875049, abstract = {The proper folding of tubulins and their incorporation into microtubules consist of a series of reactions, in which evolutionarily conserved proteins, cofactors A to E, play a vital role. We have cloned a fission yeast gene (alp41+) which encodes a highly conserved small GTP-binding protein homologous to budding yeast CIN4 and human ARF-like Arl2. alp41+ is essential, disruption of which results in microtubule dysfunction and growth polarity defects. Genetic analysis indicates that Alp41 plays a crucial role in the cofactor-dependent pathway, in which it functions upstream of the cofactor D homologue Alp1D and possibly in concert with Alp21E.}, author = {Radcliffe, Pippa A. and Vardy, Leah and Toda, Takashi}, citeulike-article-id = {1875049}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0014-5793(00)01202-3}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T36-3YJXWY9-M/2/b3d502732e68f101df38ea89d717a3db}, day = {18}, doi = {10.1016/S0014-5793(00)01202-3}, journal = {FEBS Letters}, keywords = {alp41, arl2}, month = {February}, number = {1}, pages = {84--88}, posted-at = {2007-11-06 19:35:10}, priority = {2}, title = {A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast}, url = {http://dx.doi.org/10.1016/S0014-5793(00)01202-3}, volume = {468}, year = {2000} }

TY - JOUR ID - citeulike:1875049 L3 - citeulike-article-id:1875049 N2 - The proper folding of tubulins and their incorporation into microtubules consist of a series of reactions, in which evolutionarily conserved proteins, cofactors A to E, play a vital role. We have cloned a fission yeast gene (alp41+) which encodes a highly conserved small GTP-binding protein homologous to budding yeast CIN4 and human ARF-like Arl2. alp41+ is essential, disruption of which results in microtubule dysfunction and growth polarity defects. Genetic analysis indicates that Alp41 plays a crucial role in the cofactor-dependent pathway, in which it functions upstream of the cofactor D homologue Alp1D and possibly in concert with Alp21E. IS - 1 JF - FEBS Letters EP - 88 TI - A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast VL - 468 SP - 84 KW - alp41 KW - arl2 AU - Radcliffe, Pippa AU - Vardy, Leah AU - Toda, Takashi PY - 2000/02/18/ UR - http://dx.doi.org/10.1016/S0014-5793(00)01202-3 ER -