PP2A: the expected tumor suppressor Export

@article{citeulike:2609066, abstract = {PP2A is one of the few serine/threonine-specific phosphatases in the cell, and its complex structure and regulation guarantees its many different functions. Some viruses have chosen to target this enzyme system in order to manage the host cell machinery for their own profit and to program cells into a malignant state. Suppression of PR61/B'[gamma], a specific third regulatory subunit of PP2A, can substitute for the viral SV40 protein small t antigen in causing tumorigenic transformation of several human cell lines -- provided that telomerase, SV40 large T antigen and oncogenic Ras are also present. Accumulation of c-Myc seems to be the common denominator.}, author = {Janssens, Veerle and Goris, Jozef and Van Hoof, Christine}, booktitle = {Oncogenes and cell proliferation}, citeulike-article-id = {2609066}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.gde.2004.12.004}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6VS0-4F2V5NY-3/2/e10eaabe12c516f9827f2912cb322a95}, doi = {10.1016/j.gde.2004.12.004}, journal = {Current Opinion in Genetics \& Development}, keywords = {cancer, pp2a, signalling}, month = {February}, number = {1}, pages = {34--41}, posted-at = {2008-03-28 18:13:13}, priority = {2}, title = {PP2A: the expected tumor suppressor}, url = {http://dx.doi.org/10.1016/j.gde.2004.12.004}, volume = {15}, year = {2005} }

TY - JOUR ID - citeulike:2609066 L3 - citeulike-article-id:2609066 N2 - PP2A is one of the few serine/threonine-specific phosphatases in the cell, and its complex structure and regulation guarantees its many different functions. Some viruses have chosen to target this enzyme system in order to manage the host cell machinery for their own profit and to program cells into a malignant state. Suppression of PR61/B'[gamma], a specific third regulatory subunit of PP2A, can substitute for the viral SV40 protein small t antigen in causing tumorigenic transformation of several human cell lines -- provided that telomerase, SV40 large T antigen and oncogenic Ras are also present. Accumulation of c-Myc seems to be the common denominator. IS - 1 JF - Current Opinion in Genetics & Development EP - 41 TI - PP2A: the expected tumor suppressor VL - 15 T2 - Oncogenes and cell proliferation SP - 34 KW - cancer KW - pp2a KW - signalling AU - Janssens, Veerle AU - Goris, Jozef AU - Van Hoof, Christine PY - 2005/02// UR - http://dx.doi.org/10.1016/j.gde.2004.12.004 ER -