Role of tethering factors in secretory membrane traffic. Export

@article{citeulike:3916865, abstract = {Coiled-coil and multisubunit tethers have emerged as key regulators of membrane traffic and organellar architecture. The restricted subcellular localization of tethers and their ability to interact with Rabs and soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) suggests that tethers participate in determining the specificity of membrane fusion. An accepted model of tether function considers them molecular "bridges" that link opposing membranes before SNARE pairing. This model has been extended by findings in various experimental systems, suggesting that tethers may have other functions. Recent reports implicate tethers in the assembly of SNARE complexes, cargo selection and transit, cytoskeletal events, and localized attachment of regulatory proteins. A concept of tethers as scaffolding machines that recruit protein components involved in varied cellular responses is emerging. In this model, tethers function as integration switches that simultaneously transmit information to coordinate distinct processes required for membrane traffic.}, author = {Sztul, E. and Lupashin, V.}, citeulike-article-id = {3916865}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/ajpcell.00293.2005}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16338975}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16338975}, doi = {10.1152/ajpcell.00293.2005}, issn = {0363-6143}, journal = {American journal of physiology. Cell physiology}, keywords = {golgi, rab}, month = {January}, number = {1}, posted-at = {2009-01-20 21:39:05}, priority = {2}, title = {Role of tethering factors in secretory membrane traffic.}, url = {http://dx.doi.org/10.1152/ajpcell.00293.2005}, volume = {290}, year = {2006} }

TY - JOUR ID - citeulike:3916865 L3 - citeulike-article-id:3916865 N2 - Coiled-coil and multisubunit tethers have emerged as key regulators of membrane traffic and organellar architecture. The restricted subcellular localization of tethers and their ability to interact with Rabs and soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) suggests that tethers participate in determining the specificity of membrane fusion. An accepted model of tether function considers them molecular "bridges" that link opposing membranes before SNARE pairing. This model has been extended by findings in various experimental systems, suggesting that tethers may have other functions. Recent reports implicate tethers in the assembly of SNARE complexes, cargo selection and transit, cytoskeletal events, and localized attachment of regulatory proteins. A concept of tethers as scaffolding machines that recruit protein components involved in varied cellular responses is emerging. In this model, tethers function as integration switches that simultaneously transmit information to coordinate distinct processes required for membrane traffic. IS - 1 JF - American journal of physiology. Cell physiology SN - 0363-6143 TI - Role of tethering factors in secretory membrane traffic. VL - 290 KW - golgi KW - rab AU - Sztul, E AU - Lupashin, V PY - 2006/01// UR - http://dx.doi.org/10.1152/ajpcell.00293.2005 ER -