Function of mitochondrial Stat3 in cellular respiration. Export

@article{citeulike:4517814, abstract = {Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3(-/-) cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.}, author = {Wegrzyn, J. and Potla, R. and Chwae, Y. J. and Sepuri, N. B. and Zhang, Q. and Koeck, T. and Derecka, M. and Szczepanek, K. and Szelag, M. and Gornicka, A. and Moh, A. and Moghaddas, S. and Chen, Q. and Bobbili, S. and Cichy, J. and Dulak, J. and Baker, D. P. and Wolfman, A. and Stuehr, D. and Hassan, M. O. and Fu, X. Y. and Avadhani, N. and Drake, J. I. and Fawcett, P. and Lesnefsky, E. J. and Larner, A. C.}, citeulike-article-id = {4517814}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1164551}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19131594}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19131594}, day = {6}, doi = {10.1126/science.1164551}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {arl2, bart, stat3}, month = {February}, number = {5915}, pages = {793--797}, posted-at = {2009-05-14 11:44:46}, priority = {2}, title = {Function of mitochondrial Stat3 in cellular respiration.}, url = {http://dx.doi.org/10.1126/science.1164551}, volume = {323}, year = {2009} }

TY - JOUR ID - citeulike:4517814 L3 - citeulike-article-id:4517814 N2 - Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3(-/-) cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis. IS - 5915 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 797 TI - Function of mitochondrial Stat3 in cellular respiration. VL - 323 SP - 793 KW - arl2 KW - bart KW - stat3 AU - Wegrzyn, J AU - Potla, R AU - Chwae, YJ AU - Sepuri, NB AU - Zhang, Q AU - Koeck, T AU - Derecka, M AU - Szczepanek, K AU - Szelag, M AU - Gornicka, A AU - Moh, A AU - Moghaddas, S AU - Chen, Q AU - Bobbili, S AU - Cichy, J AU - Dulak, J AU - Baker, DP AU - Wolfman, A AU - Stuehr, D AU - Hassan, MO AU - Fu, XY AU - Avadhani, N AU - Drake, JI AU - Fawcett, P AU - Lesnefsky, EJ AU - Larner, AC PY - 2009/02/06/ UR - http://dx.doi.org/10.1126/science.1164551 ER -