Two B or not two B? Overview of the rapidly expanding B-box family of proteins. Export

@article{citeulike:510647, abstract = {The B-box gene family represents a large number of genes involved in functions such as axial patterning, growth control, differentiation, and transcriptional regulation. These genes possess several conserved motifs that always include a B-box zinc binding motif associated with various other motifs such as the RING zinc finger, an alpha-helical coiled-coil, the rfp or B30.2 motif, propeller domain, and the NHL motif in various combinations. Mutations or rearrangements in several B-box family members are associated with human diseases and cancers such as familial Mediterranean fever (FMF), Optiz/BBB syndrome, acute promyelocytic leukemia, mulibrey nanism, and thyroid carcinomas. This suggests that members of this gene family play important roles in fundamental biological processes. Here we discuss the known members of this rapidly expanding protein family.}, address = {Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.}, author = {Torok, M. and Etkin, L. D.}, citeulike-article-id = {510647}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11428128}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11428128}, issn = {0301-4681}, journal = {Differentiation}, keywords = {domain, ring}, month = {March}, number = {3}, pages = {63--71}, posted-at = {2006-02-18 16:19:57}, priority = {2}, title = {Two B or not two B? Overview of the rapidly expanding B-box family of proteins.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11428128}, volume = {67}, year = {2001} }

TY - JOUR ID - citeulike:510647 L3 - citeulike-article-id:510647 N2 - The B-box gene family represents a large number of genes involved in functions such as axial patterning, growth control, differentiation, and transcriptional regulation. These genes possess several conserved motifs that always include a B-box zinc binding motif associated with various other motifs such as the RING zinc finger, an alpha-helical coiled-coil, the rfp or B30.2 motif, propeller domain, and the NHL motif in various combinations. Mutations or rearrangements in several B-box family members are associated with human diseases and cancers such as familial Mediterranean fever (FMF), Optiz/BBB syndrome, acute promyelocytic leukemia, mulibrey nanism, and thyroid carcinomas. This suggests that members of this gene family play important roles in fundamental biological processes. Here we discuss the known members of this rapidly expanding protein family. IS - 3 JF - Differentiation SN - 0301-4681 AD - Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. EP - 71 TI - Two B or not two B? Overview of the rapidly expanding B-box family of proteins. VL - 67 SP - 63 KW - domain KW - ring AU - Torok, M AU - Etkin, LD PY - 2001/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/11428128 ER -