The Shared Health Research Information Network (SHRINE): A Prototype Federated Query Tool for Clinical Data Repositories Export

@article{citeulike:5095263, abstract = {We developed a prototype Shared Health Research Information Network (SHRINE) to identify the technical, regulatory, and political challenges of creating a federated query tool for clinical data repositories. Separate Institutional Review Boards (IRBs) at Harvard's three largest affiliated health centers approved use of their data, and the Harvard Medical School IRB approved building a Query Aggregator Interface that can simultaneously send queries to each hospital and display aggregate counts of the number of matching patients. Our experience creating three local repositories using the open source Informatics for Integrating Biology and the Bedside (i2b2) platform can be used as a roadmap for other institutions. We are actively working with the IRBs and regulatory groups to develop procedures that will ultimately allow investigators to obtain identified patient data and biomaterials through SHRINE. This will guide us in creating a future technical architecture that is scalable to a national level, compliant with ethical guidelines, and protective of the interests of the participating hospitals.}, author = {Weber, G. M. and Murphy, S. N. and McMurry, A. J. and MacFadden, D. and Nigrin, D. J. and Churchill, S. and Kohane, I. S.}, citeulike-article-id = {5095263}, citeulike-linkout-0 = {http://dx.doi.org/10.1197/jamia.M3191}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19567788}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19567788}, day = {30}, doi = {10.1197/jamia.M3191}, issn = {1067-5027}, journal = {Journal of the American Medical Informatics Association}, keywords = {i2b2}, month = {June}, number = {5}, pages = {624--630}, posted-at = {2009-07-09 09:46:09}, priority = {5}, title = {The Shared Health Research Information Network (SHRINE): A Prototype Federated Query Tool for Clinical Data Repositories}, url = {http://dx.doi.org/10.1197/jamia.M3191}, volume = {16}, year = {2009} }

TY - JOUR ID - citeulike:5095263 L3 - citeulike-article-id:5095263 N2 - We developed a prototype Shared Health Research Information Network (SHRINE) to identify the technical, regulatory, and political challenges of creating a federated query tool for clinical data repositories. Separate Institutional Review Boards (IRBs) at Harvard's three largest affiliated health centers approved use of their data, and the Harvard Medical School IRB approved building a Query Aggregator Interface that can simultaneously send queries to each hospital and display aggregate counts of the number of matching patients. Our experience creating three local repositories using the open source Informatics for Integrating Biology and the Bedside (i2b2) platform can be used as a roadmap for other institutions. We are actively working with the IRBs and regulatory groups to develop procedures that will ultimately allow investigators to obtain identified patient data and biomaterials through SHRINE. This will guide us in creating a future technical architecture that is scalable to a national level, compliant with ethical guidelines, and protective of the interests of the participating hospitals. IS - 5 JF - Journal of the American Medical Informatics Association SN - 1067-5027 EP - 630 TI - The Shared Health Research Information Network (SHRINE): A Prototype Federated Query Tool for Clinical Data Repositories VL - 16 SP - 624 KW - i2b2 AU - Weber, GM AU - Murphy, SN AU - McMurry, AJ AU - MacFadden, D AU - Nigrin, DJ AU - Churchill, S AU - Kohane, IS PY - 2009/06/30/ UR - http://dx.doi.org/10.1197/jamia.M3191 ER -