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Anal Bioanal Chem In Analytical and Bioanalytical Chemistry, Vol. 391, No. 1. (2 February 2008), pp. 21-31, doi:10.1007/s00216-008-1879-1 Key: citeulike:2352940
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In this review, instrumental aspects of comprehensive two-dimensional liquid chromatography coupled with mass spectrometry are presented. The milestones of LC×LC are briefly summarized. Instrument configuration, selection of experimental conditions, the different interfaces used in the system and the current applications of LC×LC–MS systems are described.
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